Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Sign Up to like & getrecommendations! Published in 2018 at "Developmental cell"
DOI: 10.1016/j.devcel.2018.05.022
Abstract: Disruptive mutations in chromatin remodeler CHD8 cause autism spectrum disorders, exhibiting widespread white matter abnormalities; however, the underlying mechanisms remain elusive. We show that cell-type specific Chd8 deletion in oligodendrocyte progenitors, but not in neurons,… read more here.
Keywords: histone methyltransferase; chromatin landscape; chd8; myelination ... See more keywords
SU14 TRANSCRIPTOME ANALYSIS OF WNT7A-MEDIATED GENE EXPRESSION IN HUMAN NEURAL PROGENITOR CELLS DERIVED FROM CONTROL AND CHD8 HAPLOINSUFFICIENT INDUCED PLURIPOTENT STEM CELLS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.203
Abstract: Background CHD8 (Chromodomain Helicase DNA Binding Protein 8) codes for a member of the CHD family of chromatin-remodeling factors and is one of the most commonly mutated genes in Autism Spectrum Disorders (ASD) identified in… read more here.
Keywords: wnt7a; control; gene expression; chd8 ... See more keywords
Germline Chd8 haploinsufficiency alters brain development in mouse
Sign Up to like & getrecommendations! Published in 2017 at "Nature Neuroscience"
DOI: 10.1038/nn.4592
Abstract: The chromatin remodeling gene CHD8 represents a central node in neurodevelopmental gene networks implicated in autism. We examined the impact of germline heterozygous frameshift Chd8 mutation on neurodevelopment in mice. Chd8+/del5 mice displayed normal social… read more here.
Keywords: del5 mice; chd8; chd8 del5; brain development ... See more keywords
Overexpression of microRNA-221 promotes the differentiation of stem cells from human exfoliated deciduous teeth to neurons through activation of Wnt/β-catenin pathway via inhibition of CHD8
Sign Up to like & getrecommendations! Published in 2020 at "Cell Cycle"
DOI: 10.1080/15384101.2020.1816308
Abstract: ABSTRACT microRNAs have been proved to function in some processes of differentiation and the effect is favorable. At present, the differentiation of stem cells is not so ideal because of the high expenses and inaccessibility.… read more here.
Keywords: catenin pathway; mir 221; chd8; wnt catenin ... See more keywords
High glucose‐ROS conditions enhance the progression in cholangiocarcinoma via upregulation of MAN2A2 and CHD8
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14719
Abstract: Diabetes is a major risk factor in the development and progression of several cancers including cholangiocarcinoma (CCA). However, the molecular mechanism by which hyperglycemia potentiates progression of CCA is not clearly understood. Here, we showed… read more here.
Keywords: man2a2 chd8; high glucose; chd8; progression ... See more keywords
The clinical presentation caused by truncating CHD8 variants
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Genetics"
DOI: 10.1111/cge.13554
Abstract: Variants in the chromodomain helicase DNA‐binding protein 8 (CHD8) have been associated with intellectual disability (ID), autism spectrum disorders (ASDs) and overgrowth and CHD8 is one of the causative genes for OGID (overgrowth and ID).… read more here.
Keywords: chd8 variants; presentation caused; caused truncating; clinical presentation ... See more keywords
The chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020009997
Abstract: The Chd8 gene encodes a member of the chromodomain helicase DNA-binding (CHD) family of SNF2H-like adenosine triphosphate (ATP)-dependent chromatin remodeler, the mutations of which define a subtype of autism spectrum disorders. Increasing evidence from recent… read more here.
Keywords: p53 protein; stem progenitor; chd8; hematopoietic stem ... See more keywords
Chd8 mutation in oligodendrocytes alters microstructure and functional connectivity in the mouse brain
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Brain"
DOI: 10.1186/s13041-020-00699-x
Abstract: CHD8 encodes a chromatin-remodeling factor and is one of the most recurrently mutated genes in individuals with autism spectrum disorder (ASD). Although we have recently shown that mice heterozygous for Chd8 mutation manifest myelination defects… read more here.
Keywords: microstructure functional; chd8 mutation; chd8; brain ... See more keywords
Common CHD8 Genomic Targets Contrast With Model-Specific Transcriptional Impacts of CHD8 Haploinsufficiency
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00481
Abstract: The packaging of DNA into chromatin determines the transcriptional potential of cells and is central to eukaryotic gene regulation. Case sequencing studies have revealed mutations to proteins that regulate chromatin state, known as chromatin remodeling… read more here.
Keywords: transcriptional impacts; chd8 genomic; chromatin; chd8 ... See more keywords
Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1022306
Abstract: Autism spectrum disorders (ASD) are ~4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (~4:1), although the underlying mechanism remains unclear. Chd8-mutant mice with a C-terminal… read more here.
Keywords: age differential; chd8; differential sexual; mice ... See more keywords
Single-Cell Transcriptomics Supports a Role of CHD8 in Autism
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063261
Abstract: Chromodomain helicase domain 8 (CHD8) is one of the most frequently mutated and most penetrant genes in the autism spectrum disorder (ASD). Individuals with CHD8 mutations show leading symptoms of autism, macrocephaly, and facial dysmorphisms.… read more here.
Keywords: single cell; transcriptomics supports; autism; cell transcriptomics ... See more keywords