Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
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DOI: 10.1021/acs.jmedchem.2c01585
Abstract: Therapeutic interventions are being developed for Huntington's disease (HD), a hallmark of which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to human testing of two [11C]-PET ligands for aggregated mHTT, attributes for further… read more here.
Keywords: chdi 650; design evaluation; mutant huntingtin; ligand ... See more keywords