Assessment of Clinical Activity of PD-1 Checkpoint Inhibitor Combination Therapies Reported in Clinical Trials.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2019.20833
Abstract: Importance Because cancer drugs given in combination have the potential for increased tumor-cell killing, finding the best combination partners for programmed cell death 1 (PD-1) checkpoint inhibitors could improve clinical outcomes for patients with cancer.… read more here.
Keywords: combination; inhibitor; clinical trials; checkpoint ... See more keywords
Immune checkpoint gene VSIR predicts patient prognosis in acute myeloid leukemia and myelodysplastic syndromes
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DOI: 10.1002/cam4.5409
Abstract: Immune checkpoint proteins play critical functions during the immune response to cancer and have been targeted by immune checkpoint blockade therapy. V‐domain Ig suppressor of T cell activation (VSIR) is one of these immune checkpoint… read more here.
Keywords: checkpoint; acute myeloid; myeloid leukemia; immune checkpoint ... See more keywords
Monocyte chemoattractant protein 1 as a potential biomarker for immune checkpoint inhibitor‐associated neurotoxicity
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DOI: 10.1002/cam4.5695
Abstract: Oncological patients can benefit substantially from treatment with immune checkpoint inhibitors (ICI). However, there is a growing awareness of immune‐related adverse events (irAE). Especially ICI‐mediated neurological adverse events (nAE(+)), are tough to diagnose and biomarkers… read more here.
Keywords: protein potential; immune checkpoint; chemoattractant protein; monocyte chemoattractant ... See more keywords
Immune checkpoint inhibitors in challenging populations
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DOI: 10.1002/cncr.30642
Abstract: Immune checkpoint inhibitors, including those targeting the programmed cell death 1/programmed cell death ligand 1 and cytotoxic T lymphocyte antigen 4 pathways, are revolutionizing cancer therapeutics. Both activity and toxicities largely stem from unleashing tumor‐… read more here.
Keywords: challenging populations; immune checkpoint; checkpoint inhibitors; checkpoint ... See more keywords
Immune checkpoint inhibitors for hepatocellular carcinoma
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DOI: 10.1002/cncr.32076
Abstract: The position of immunotherapy as a pillar of systemic cancer treatment has been firmly established over the past decade. Immune checkpoint inhibitors are a welcome option for patients with different malignancies. This is in part… read more here.
Keywords: hepatocellular carcinoma; immune checkpoint; checkpoint inhibitors; checkpoint ... See more keywords
High‐dimensional single‐cell proteomics analysis identifies immune checkpoint signatures and therapeutic targets in ulcerative colitis
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847862
Abstract: Immune checkpoints are regulators of immune cells and play key roles in the modulation of immune responses. The role of checkpoints in autoimmune disease is poorly understood but likely to be central since checkpoint inhibition… read more here.
Keywords: single cell; high dimensional; immune cell; checkpoint ... See more keywords
The pancreatic cancer immune tumor microenvironment is negatively remodeled by gemcitabine while TGF‐β receptor plus dual checkpoint inhibition maintains antitumor immune cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23401
Abstract: Pancreatic ductal adenocarcinoma (PDA) tumors have a highly immunosuppressive desmoplastic tumor microenvironment (TME) where immune checkpoint inhibition (ICI) therapy has been exceptionally ineffective. Transforming growth factor‐β (TGF‐β) receptor activation leads to cancer and immune cell… read more here.
Keywords: inhibition; tgf receptor; checkpoint; tumor ... See more keywords
A Selective Nano Cell Cycle Checkpoint Inhibitor Overcomes Leukemia Chemoresistance.
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DOI: 10.1002/smll.202300736
Abstract: Cell cycle checkpoint activation promotes DNA damage repair, which is highly associated with the chemoresistance of various cancers including acute myeloid leukemia (AML). Selective cell cycle checkpoint inhibitors are strongly demanded to overcome chemoresistance, but… read more here.
Keywords: chemoresistance; checkpoint; cell cycle; cycle checkpoint ... See more keywords
Immune Checkpoint Inhibitors (ICIs)-Related Cardiotoxicity.
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DOI: 10.1007/978-3-030-41008-7_15
Abstract: The growing success of immune checkpoint inhibitors (ICIs) has led to effectively treating several types of cancers. Even though their use has been associated with the development of cardiac adverse effects, which may decrease the… read more here.
Keywords: immune checkpoint; checkpoint inhibitors; related cardiotoxicity; icis related ... See more keywords
Clinical characteristics of patient selection and imaging predictors of outcome in solid tumors treated with checkpoint-inhibitors
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DOI: 10.1007/s00259-017-3802-5
Abstract: The rapidly evolving knowledge on tumor immunology and the continuous implementation of immunotherapy in cancer have recently led to the FDA and EMA approval of several checkpoint inhibitors as immunotherapic agents in clinical practice. Anti-CTLA-4,… read more here.
Keywords: patient selection; solid tumors; checkpoint inhibitors; response ... See more keywords
Patterns of immune checkpoint protein expression in MYC-overexpressing aggressive B-cell non-Hodgkin lymphomas
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DOI: 10.1007/s00262-020-02708-3
Abstract: Given the poor prognosis of MYC-overexpressing diffuse large B cell lymphoma (DLBCL) and B cell lymphoma unclassifiable with features intermediate between DLBCL and Burkitt lymphoma/high grade B cell lymphoma (BCLU/HGBL), and preclinical data suggesting that… read more here.
Keywords: immune checkpoint; expression; myc overexpressing; checkpoint ... See more keywords