Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201903410
Abstract: Abstract The evolutionary dynamics of tumor‐associated neoantigens carry information about drug sensitivity and resistance to the immune checkpoint blockade (ICB). However, the spectrum of somatic mutations is highly heterogeneous among patients, making it difficult to… read more here.
Keywords: checkpoint blockade; small cell; circulating tumor; non small ... See more keywords
Training the microbiota to increase immune checkpoint blockade and to reduce toxicity.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250183
Abstract: There is no doubt that immunotherapy, particularly Immune checkpoint blockade (ICB), has drastically improved treatment of metastatic cancer patients. Microbiota composition has been proposed to be one of the reasons for failure or success. ICB… read more here.
Keywords: immune checkpoint; microbiota increase; toxicity; reduce toxicity ... See more keywords
Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30157
Abstract: Nodular regenerative hyperplasia (NRH) is a rare condition characterized by diffuse, benign transformation of hepatic parenchyma into regenerative nodules, and is an under-recognized cause of portal hypertension. We present a case of NRH associated with… read more here.
Keywords: regenerative hyperplasia; immune checkpoint; nodular regenerative; checkpoint blockade ... See more keywords
Nano-Econazole Enhanced PD-L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma.
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DOI: 10.1002/smll.202207201
Abstract: Insufficienct T lymphocyte infiltration and unresponsiveness to immune checkpoint blockade therapy are still major difficulties for the clinical treatment of pancreatic ductal adenocarcinoma (PDAC). Although econazole has shown promise in inhibiting PDAC growth, its poor… read more here.
Keywords: antitumor; therapy; blockade; pdac ... See more keywords
Hsp70-Targeting and Size-Tunable Nanoparticles Combine with PD-1 Checkpoint Blockade to Treat Glioma.
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DOI: 10.1002/smll.202300570
Abstract: Invasive glioma usually disrupts the integrity of the blood-brain barrier (BBB), making the delivery of nanodrugs across the BBB possible, but sufficient targeting ability is still avidly needed to improve drug accumulation in glioma. Membrane-bound… read more here.
Keywords: size tunable; checkpoint blockade; glioma; hsp70 targeting ... See more keywords
Anti-PD-1 antibody-mediated activation of type 17 T-cells undermines checkpoint blockade therapy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02795-2
Abstract: Tumors that develop in the genetic LSL-K-ras G12D murine lung cancer model are resistant to anti-PD-1 antibody treatment. Analysis of tumor-bearing lungs from anti-PD-1-treated mice revealed an up to 2.5-fold increase in IL-17-producing T-cells, with… read more here.
Keywords: checkpoint blockade; anti antibody; activation; therapy ... See more keywords
PD-1-PD-L1 immune-checkpoint blockade in malignant lymphomas
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DOI: 10.1007/s00277-017-3176-6
Abstract: Tumor cells can evade immune surveillance through overexpressing the ligands of checkpoint receptors on tumor cells or adjacent cells, leading T cells to anergy or exhaustion. Growing evidence of the interaction between tumor cells and… read more here.
Keywords: checkpoint blockade; immune checkpoint; lymphomas; tumor cells ... See more keywords
Current challenges of hematologic complications due to immune checkpoint blockade: a comprehensive review
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04690-x
Abstract: Immune checkpoint blockade has demonstrated durable clinical benefits in a variety of malignancies. These immune checkpoint inhibitors (ICIs) produce unwanted autoimmune reactions due to an impaired self-tolerance. Hematologic immune-related adverse events (heme-irAEs) have been increasingly… read more here.
Keywords: checkpoint blockade; immune checkpoint; current challenges; checkpoint ... See more keywords
Immune Checkpoint Blockade and Hematopoietic Stem Cell Transplant
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DOI: 10.1007/s11899-017-0362-5
Abstract: Allogeneic hematopoietic stem cell transplant (HSCT) relies primarily upon graft-versus-tumor activity for cancer eradication. Relapse remains the principal cause of treatment failure after HSCT, implying frequent immune escape, which in at least some cases, appears… read more here.
Keywords: checkpoint blockade; immune checkpoint; stem cell; hematopoietic stem ... See more keywords
Cancer-cell-biomimetic nanoparticles systemically eliminate hypoxia tumors by synergistic chemotherapy and checkpoint blockade immunotherapy
Sign Up to like & getrecommendations! Published in 2021 at "Acta Pharmaceutica Sinica B"
DOI: 10.1016/j.apsb.2021.10.010
Abstract: Abstract Checkpoint blockade-based immunotherapy has shown unprecedented effect in cancer treatments, but its clinical implementation has been restricted by the low host antitumor response rate. Recently, chemotherapy is well recognized to activate the immune system… read more here.
Keywords: blockade; cancer cell; checkpoint blockade; cancer ... See more keywords
Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.08.005
Abstract: We analyze the transcriptome of baseline and on-therapy tumor biopsies from 101 patients with advanced melanoma treated with nivolumab (anti-PD-1) alone or combined with ipilimumab (anti-CTLA-4). We find that T cell infiltration and interferon-γ (IFN-γ) signaling… read more here.
Keywords: checkpoint blockade; immune checkpoint; blockade therapy; response ... See more keywords