Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Science"
DOI: 10.1002/advs.201903410
Abstract: Abstract The evolutionary dynamics of tumor‐associated neoantigens carry information about drug sensitivity and resistance to the immune checkpoint blockade (ICB). However, the spectrum of somatic mutations is highly heterogeneous among patients, making it difficult to… read more here.
Keywords: checkpoint blockade; small cell; circulating tumor; non small ... See more keywords
A Phase IB Trial of Selinexor in Combination With Immune Checkpoint Blockade in Patients With Advanced Renal Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Medicine"
DOI: 10.1002/cam4.70280
Abstract: Selinexor (SEL) is a nuclear exportin 1 inhibitor that blocks the transport of nuclear proteins, including tumor suppressors, to the cytoplasm. Preclinical data suggest that the combination of SEL with checkpoint blockade may result in… read more here.
Keywords: combination; phase trial; trial selinexor; checkpoint blockade ... See more keywords
Training the microbiota to increase immune checkpoint blockade and to reduce toxicity.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250183
Abstract: There is no doubt that immunotherapy, particularly Immune checkpoint blockade (ICB), has drastically improved treatment of metastatic cancer patients. Microbiota composition has been proposed to be one of the reasons for failure or success. ICB… read more here.
Keywords: immune checkpoint; microbiota increase; toxicity; reduce toxicity ... See more keywords
Nodular Regenerative Hyperplasia Associated With Immune Checkpoint Blockade
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DOI: 10.1002/hep.30157
Abstract: Nodular regenerative hyperplasia (NRH) is a rare condition characterized by diffuse, benign transformation of hepatic parenchyma into regenerative nodules, and is an under-recognized cause of portal hypertension. We present a case of NRH associated with… read more here.
Keywords: regenerative hyperplasia; immune checkpoint; nodular regenerative; checkpoint blockade ... See more keywords
Nano-Econazole Enhanced PD-L1 Checkpoint Blockade for Synergistic Antitumor Immunotherapy against Pancreatic Ductal Adenocarcinoma.
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DOI: 10.1002/smll.202207201
Abstract: Insufficienct T lymphocyte infiltration and unresponsiveness to immune checkpoint blockade therapy are still major difficulties for the clinical treatment of pancreatic ductal adenocarcinoma (PDAC). Although econazole has shown promise in inhibiting PDAC growth, its poor… read more here.
Keywords: antitumor; therapy; blockade; pdac ... See more keywords
Hsp70-Targeting and Size-Tunable Nanoparticles Combine with PD-1 Checkpoint Blockade to Treat Glioma.
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DOI: 10.1002/smll.202300570
Abstract: Invasive glioma usually disrupts the integrity of the blood-brain barrier (BBB), making the delivery of nanodrugs across the BBB possible, but sufficient targeting ability is still avidly needed to improve drug accumulation in glioma. Membrane-bound… read more here.
Keywords: size tunable; checkpoint blockade; glioma; hsp70 targeting ... See more keywords
Copper-Doped Polydopamine Nanoparticles-Mediated GSH/GPX4-Depleted Ferroptosis and Cuproptosis Sensitizes Lung Tumor to Checkpoint Blockade Immunotherapy.
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DOI: 10.1002/smll.202503208
Abstract: Immune checkpoint blockade (ICB) therapy offers hope for improved outcomes in lung cancer treatment, but its effectiveness is restricted by the presence of an immunosuppressive tumor microenvironment (TME), resulting in a limited response rate (<… read more here.
Keywords: ferroptosis cuproptosis; cuproptosis; checkpoint blockade; lung tumor ... See more keywords
Anti-PD-1 antibody-mediated activation of type 17 T-cells undermines checkpoint blockade therapy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02795-2
Abstract: Tumors that develop in the genetic LSL-K-ras G12D murine lung cancer model are resistant to anti-PD-1 antibody treatment. Analysis of tumor-bearing lungs from anti-PD-1-treated mice revealed an up to 2.5-fold increase in IL-17-producing T-cells, with… read more here.
Keywords: checkpoint blockade; anti antibody; activation; therapy ... See more keywords
PD-1-PD-L1 immune-checkpoint blockade in malignant lymphomas
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DOI: 10.1007/s00277-017-3176-6
Abstract: Tumor cells can evade immune surveillance through overexpressing the ligands of checkpoint receptors on tumor cells or adjacent cells, leading T cells to anergy or exhaustion. Growing evidence of the interaction between tumor cells and… read more here.
Keywords: checkpoint blockade; immune checkpoint; lymphomas; tumor cells ... See more keywords
Current challenges of hematologic complications due to immune checkpoint blockade: a comprehensive review
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DOI: 10.1007/s00277-021-04690-x
Abstract: Immune checkpoint blockade has demonstrated durable clinical benefits in a variety of malignancies. These immune checkpoint inhibitors (ICIs) produce unwanted autoimmune reactions due to an impaired self-tolerance. Hematologic immune-related adverse events (heme-irAEs) have been increasingly… read more here.
Keywords: checkpoint blockade; immune checkpoint; current challenges; checkpoint ... See more keywords
Neoadjuvant triple-modality therapy with immune checkpoint blockade, anti-angiogenesis, and chemotherapy enhances pathologic response and survival in locally advanced and metastatic colorectal cancer: a multicenter cohort study
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Colorectal Disease"
DOI: 10.1007/s00384-025-04945-3
Abstract: The current study seeks to investigate the clinical outcomes of combining immune checkpoint blockade, anti-angiogenesis, and chemotherapy in neoadjuvant treatment for individuals diagnosed with locally advanced (high-risk Stage III or initially unresectable Stage III) or… read more here.
Keywords: colorectal cancer; cancer; immune checkpoint; group ... See more keywords