IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti-viral activity
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24293
Abstract: Interleukin-1 receptor 8 (IL-1R8, also known as single immunoglobulin IL-1R-related receptor, SIGIRR, or TIR8) is a member of the IL-1 receptor (ILR) family with distinct structural and functional characteristics, acting as a negative regulator of… read more here.
Keywords: cells regulating; 1r8 checkpoint; regulating anti; checkpoint ... See more keywords
Abstract 1689: Ovarian tumor-induced CISH expression is an immune checkpoint for NK cells
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-1689
Abstract: Background: Non-specificity of symptoms in early stages of ovarian cancer (OVCA), lack of an early detection test and inefficient chemotherapy regimens lead to frequent recurrence and high mortality rates. OVCA differs from other malignancies as… read more here.
Keywords: immune checkpoint; checkpoint cells; late stages; cish expression ... See more keywords