Immune mediated neuropathy following checkpoint immunotherapy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2017.07.014
Abstract: Checkpoint immunotherapy has revolutionised cancer therapy and is now standard treatment for many malignancies including metastatic melanoma. Acute inflammatory neuropathies, often labelled as Guillain-Barre syndrome, are an uncommon but potentially severe complication of checkpoint immunotherapy… read more here.
Keywords: neuropathy following; checkpoint immunotherapy; following checkpoint; therapy ... See more keywords
IRAK4 signaling drives resistance to checkpoint immunotherapy in pancreatic ductal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.02.035
Abstract: BACKGROUND AND AIMS Checkpoint immunotherapy is largely ineffective in pancreatic ductal adenocarcinoma (PDAC). The innate immune NF-κB pathway promotes PDAC cell survival, stromal fibrosis and is driven by IRAK4, but its impact on tumor immunity… read more here.
Keywords: pancreatic ductal; irak4; cell; checkpoint immunotherapy ... See more keywords
Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005401
Abstract: The host microbiome is polymorphic, compartmentalized, and composed of distinctive tissue microbiomes. While research in the field of cancer immunotherapy has provided an improved understanding of the interaction with the gastrointestinal microbiome, the significance of… read more here.
Keywords: host microbiome; tumor microbiota; checkpoint immunotherapy; tumor ... See more keywords
NK Cell Dysfunction and Checkpoint Immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01999
Abstract: NK cells play important roles in the innate immune responses against tumors. The effector function of NK cells relies on the integration of activating and inhibitory signals. Emerging checkpoint receptors and molecules are being revealed… read more here.
Keywords: cell dysfunction; cell; checkpoint immunotherapy; checkpoint ... See more keywords