Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2020.0910
Abstract: Key Points Question Can combined immune checkpoint inhibition improve overall survival (OS) in patients with advanced refractory colorectal cancer (CRC)? Findings In this randomized phase 2 study with 180 patients randomized in a 2:1 ratio… read more here.
Keywords: immune checkpoint; combined immune; supportive care; checkpoint inhibition ... See more keywords
Association of PD-L1 Expression and Other Variables With Benefit From Immune Checkpoint Inhibition in Advanced Gastroesophageal Cancer: Systematic Review and Meta-analysis of 17 Phase 3 Randomized Clinical Trials.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA oncology"
DOI: 10.1001/jamaoncol.2022.3707
Abstract: Importance Approval by the US Food and Drug Administration of immune checkpoint inhibition (ICI) for advanced gastroesophageal cancer (aGEC) irrespective of PD-L1 status has generated controversy. Exploratory analyses from individual trials indicate a lack of… read more here.
Keywords: immune checkpoint; expression; ici; analysis ... See more keywords
Treatment of Complications from Immune Checkpoint Inhibition in Patients with Lung Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-018-0562-9
Abstract: Opinion statementImmune checkpoint inhibitors have revolutionized the management of advanced NSCLC. With the intention of generating an anti-tumor immune response, ICIs can also lead to inflammatory side effects involving a wide variety of organs in… read more here.
Keywords: immune checkpoint; patients lung; treatment complications; treatment ... See more keywords
The Role of PD-1 Checkpoint Inhibition in Gynecologic Malignancies
Sign Up to like & getrecommendations! Published in 2018 at "Current Treatment Options in Oncology"
DOI: 10.1007/s11864-018-0593-2
Abstract: Opinion statementActivity of PD-1 and PD-L1 inhibitors has been demonstrated in ovarian, endometrial, and cervical cancer, with a tolerable side effect profile and the highest response rate seen in mismatch repair–deficient endometrial cancers. Other biomarkers… read more here.
Keywords: checkpoint inhibition; inhibition gynecologic; role checkpoint; gynecologic malignancies ... See more keywords
Immune Checkpoint Inhibition in Non-metastatic Non-small Cell Lung Cancer: Chance for Cure?
Sign Up to like & getrecommendations! Published in 2019 at "Drugs"
DOI: 10.1007/s40265-019-01222-w
Abstract: Immune checkpoint inhibition of programmed-death receptor 1 (PD-1) or its ligand (PD-L1) has become a standard in the treatment of metastatic non-small cell lung cancer, either as monotherapy or in combination. Recently, it could be… read more here.
Keywords: immune checkpoint; metastatic non; cell lung; checkpoint inhibition ... See more keywords
When Cold Is Hot: Immune Checkpoint Inhibition Therapy for Rhabdoid Tumors.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer cell"
DOI: 10.1016/j.ccell.2019.11.006
Abstract: Carcinogen-induced cancers typically have high mutation burdens and an inflamed microenvironment and thus are poised to respond to immune checkpoint inhibitors (ICIs). However, cancers with loss-of-function mutations in the SWI/SNF complex have few additional mutations… read more here.
Keywords: immune checkpoint; cold hot; checkpoint inhibition; checkpoint ... See more keywords
Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2020.09.059
Abstract: Trained immunity, a functional state of myeloid cells, has been proposed as a compelling immune-oncological target. Its efficient induction requires direct engagement of myeloid progenitors in the bone marrow. For this purpose, we developed a… read more here.
Keywords: immunity; checkpoint inhibition; potentiates checkpoint; trained immunity ... See more keywords
Immune Checkpoint Inhibition in Metastatic Urothelial Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "European urology"
DOI: 10.1016/j.eururo.2017.03.047
Abstract: Immune checkpoint inhibitors are a new treatment option in metastatic urothelial cancer on the basis of available phase 2 and 3 trials. Predictive biomarkers are needed. These should go beyond PD-L1 expression, which is showing… read more here.
Keywords: checkpoint inhibition; immune checkpoint; metastatic urothelial; urothelial cancer ... See more keywords
Checkpoint inhibition in the treatment of multiple myeloma: A way to boost innate-like T cell anti-tumor function?
Sign Up to like & getrecommendations! Published in 2018 at "Molecular immunology"
DOI: 10.1016/j.molimm.2018.08.019
Abstract: Multiple myeloma (MM) is a progressive monoclonal B cell malignancy, for which survival and progression largely relies on the crosstalk of tumor cells with the bone marrow (BM) microenvironment, inducing immune escape, angiogenesis, bone destruction… read more here.
Keywords: innate; multiple myeloma; checkpoint inhibition; anti tumor ... See more keywords
Checkpoint Inhibition and Infectious Diseases: A Good Thing?
Sign Up to like & getrecommendations! Published in 2019 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2019.08.004
Abstract: The mammalian immune system has evolved the capacity to detect and destroy tumor cells. Tumors utilize multiple strategies to evade host immune surveillance, including the induction of the checkpoint molecules cytotoxic T lymphocyte-associated protein 4… read more here.
Keywords: diseases good; infectious diseases; inhibition infectious; good thing ... See more keywords
Intravitreous Cutaneous Metastatic Melanoma in the Era of Checkpoint Inhibition: Unmasking and Masquerading.
Sign Up to like & getrecommendations! Published in 2019 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2019.09.018
Abstract: PURPOSE Cutaneous melanoma metastatic to the vitreous is very rare. This study investigated the clinical findings, treatment, and outcome of patients with metastatic cutaneous melanoma to the vitreous. Most patients received checkpoint inhibition for the… read more here.
Keywords: checkpoint inhibition; cutaneous melanoma; treatment;