Comparison of Long-term Survival Benefits in Trials of Immune Checkpoint Inhibitor vs Non–Immune Checkpoint Inhibitor Anticancer Agents Using ASCO Value Framework and ESMO Magnitude of Clinical Benefit Scale
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DOI: 10.1001/jamanetworkopen.2019.6803
Abstract: Key Points Question How frequently do immune checkpoint inhibitor (ICI) agents vs non-ICI agents qualify for American Society of Clinical Oncology Value Framework version 2 (ASCO-VF v2) tail-of-the-curve bonuses or European Society of Medical Oncology… read more here.
Keywords: immune checkpoint; oncology; checkpoint inhibitor; long term ... See more keywords
Intracellular Adhesion Molecule-1 Improves Responsiveness to Immune Checkpoint Inhibitor by Activating CD8+ T Cells.
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DOI: 10.1002/advs.202204378
Abstract: Immune checkpoint inhibitor (ICI) clinically benefits cancer treatment. However, the ICI responses are only achieved in a subset of patients, and the underlying mechanisms of the limited response remain unclear. 160 patients with non-small cell… read more here.
Keywords: intracellular adhesion; checkpoint inhibitor; immune checkpoint; molecule ... See more keywords
Value of Onconeural Antibodies in Checkpoint Inhibitor‐Related Toxicities
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DOI: 10.1002/ana.25764
Abstract: Value of Onconeural Antibodies in Checkpoint Inhibitor-Related Toxicities Alberto Vogrig, MD , Sergio Muñiz-Castrillo, MD , and Jérôme Honnorat, MD, PhD An increasing number of patients will be exposed to immune checkpoint inhibitors (ICIs) in… read more here.
Keywords: related toxicities; onconeural antibodies; antibodies checkpoint; value onconeural ... See more keywords
Checkpoint inhibitor/interleukin‐based combination therapy of cancer
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DOI: 10.1002/cam4.4659
Abstract: Immunotherapy using immune checkpoint inhibitors (ICIs) is the current focus in cancer immunotherapy. However, issues are raised in the area, as the recent studies showed that such therapeutic modality suffers from low durability and low… read more here.
Keywords: combination; checkpoint inhibitor; cancer; combination therapy ... See more keywords
Hyperthermia combined with immune checkpoint inhibitor therapy: Synergistic sensitization and clinical outcomes
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DOI: 10.1002/cam4.5085
Abstract: Within the field of oncotherapy, research interest regarding immunotherapy has risen to the point that it is now seen as a key application. However, inherent disadvantages of immune checkpoint inhibitors (ICIs), such as their low… read more here.
Keywords: checkpoint inhibitor; immune checkpoint; combined immune; hyperthermia combined ... See more keywords
Effectiveness and safety of immune checkpoint inhibitor monotherapy in advanced upper tract urothelial carcinoma: A multicenter, retrospective, real‐world study
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DOI: 10.1002/cam4.5796
Abstract: The effectiveness and safety of immune checkpoint inhibitor (ICI) monotherapy in advanced upper tract urothelial carcinoma (UTUC) is less reported. read more here.
Keywords: safety immune; checkpoint inhibitor; immune checkpoint; monotherapy advanced ... See more keywords
Feasibility of supervised telehealth exercise for patients with advanced melanoma receiving checkpoint inhibitor therapy.
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DOI: 10.1002/cam4.6091
Abstract: PURPOSE To determine the feasibility, safety and preliminary efficacy of a telehealth supervised exercise programme in patients with advanced melanoma receiving checkpoint inhibitor therapy. METHODS A 8-week non-randomised feasibility pilot trial utilising a telehealth delivered… read more here.
Keywords: advanced melanoma; checkpoint inhibitor; patients advanced; telehealth ... See more keywords
Immune checkpoint inhibitor gastritis is often associated with concomitant enterocolitis, which impacts the clinical course
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DOI: 10.1002/cncr.34543
Abstract: Gastrointestinal immune‐related adverse events are frequently caused by immune checkpoint inhibitors (ICIs) and often require interruption of cancer treatment. Compared with ICI colitis and enteritis, limited information exists about ICI gastritis. This study characterized clinical… read more here.
Keywords: checkpoint inhibitor; immune checkpoint; gastritis; inhibitor gastritis ... See more keywords
Effect of corticosteroid dosing on outcomes in high-grade immune checkpoint inhibitor hepatitis.
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DOI: 10.1002/hep.32215
Abstract: BACKGROUND AND AIMS Consensus guidelines recommend high-dose corticosteroids (1-2 mg/kg/day methylprednisolone equivalents) for treating grade ≥3 immune checkpoint inhibitor (ICI) hepatitis. We examined the effect of corticosteroid dosing on time to alanine aminotransferase (ALT) normalization,… read more here.
Keywords: grade immune; immune checkpoint; corticosteroid; grade ... See more keywords
Role of cardiac MRI in the diagnosis of immune checkpoint inhibitor‐associated myocarditis
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DOI: 10.1002/ijc.34169
Abstract: Immune checkpoint inhibitor (ICI)‐induced cardiotoxicity is a rare immune‐related adverse event (irAE) characterized by a high mortality rate. From a pathological point of view, this condition can result from a series of causes, including binding… read more here.
Keywords: myocarditis; checkpoint inhibitor; immune checkpoint; diagnosis ... See more keywords
Differentiation between immune checkpoint inhibitor‐related and radiation pneumonitis in lung cancer by CT radiomics and machine learning
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DOI: 10.1002/mp.15451
Abstract: Abstract Purpose Consolidation immunotherapy after completion of chemoradiotherapy has become the standard of care for unresectable locally advanced non‐small cell lung cancer and can induce potentially severe and life‐threatening adverse events, including both immune checkpoint… read more here.
Keywords: lung cancer; pneumonitis; checkpoint inhibitor; immune checkpoint ... See more keywords