Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex-vivo targeting immune checkpoint molecules.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2019.05.026
Abstract: BACKGROUND & AIMS Cholangiocarcinoma is an aggressive hepatobiliary malignancy originating from biliary tract epithelium. Whether cholangiocarcinoma is responsive to immune checkpoint antibody therapy is unknown, and knowledge of its tumor immune microenvironment is limited. We… read more here.
Keywords: immune checkpoint; microenvironment; checkpoint molecules; cholangiocarcinoma ... See more keywords
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00348-8
Abstract: Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that… read more here.
Keywords: cancer; immune checkpoint; cancer immunotherapy; checkpoint molecules ... See more keywords
Various checkpoint molecules, and tumor-infiltrating lymphocytes in common pediatric solid tumors: Possibilities for novel immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2019.1578843
Abstract: Abstract Long-term survival rates for pediatric patients with cancer have significantly improved, but novel approaches are desired for those with refractory/relapsed solid tumors. Recently, programed cell death-1/programed cell death-ligand-1 blockade has emerged as an effective… read more here.
Keywords: pediatric solid; solid tumors; checkpoint molecules; herpes virus ... See more keywords
Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1708064
Abstract: ABSTRACT The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. The resistance to ICB is likely due to compensatory upregulation of additional immune inhibitory molecules.… read more here.
Keywords: checkpoint; molecules coordinately; cd8 cells; checkpoint molecules ... See more keywords
Next generation of immune checkpoint molecules in maternal-fetal immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Immunological reviews"
DOI: 10.1111/imr.13073
Abstract: Successful pregnancy is a unique situation requires the maternal immune system to recognize and tolerate a semi-identical fetus and allow normal invasion of trophoblast cells. Although efforts have been made, the deep mechanisms of the… read more here.
Keywords: immune checkpoint; next generation; pregnancy; maternal fetal ... See more keywords
Immune checkpoint molecules and spatial transcriptome profiles according to BRAF status in acral melanoma
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.20780
Abstract: Acral melanoma (AM) shows different genomic profiles based on BRAF status, and the data on the association with BRAF and immune checkpoint molecules are lacking. read more here.
Keywords: acral melanoma; immune checkpoint; braf status; checkpoint molecules ... See more keywords
Abstract 5540: Clinical significance of soluble forms of immune checkpoint molecules in advanced esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5540
Abstract: Background: Immune checkpoint molecules such as PDL1 and CD155 are expressed on cancer cells and regulate tumor immunity by binding to ligands on immune cells. Although soluble forms of immune checkpoint molecules have been detected… read more here.
Keywords: esophageal cancer; immune checkpoint; checkpoint molecules; advanced esophageal ... See more keywords
Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0746
Abstract: Hematopoietic-derived cells are integral components of the tumor microenvironment and serve as critical mediators of tumor–host interactions. Host cells derived from myeloid and lymphoid lineages perform well-established functions linked to cancer development, progression, and response… read more here.
Keywords: multiorgan signaling; immune checkpoint; checkpoint molecules; cancer ... See more keywords
Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients
Sign Up to like & getrecommendations! Published in 2024 at "BMC Immunology"
DOI: 10.1186/s12865-024-00603-5
Abstract: Background Imbalanced immune responses are involved in developing preeclampsia (PE). We wish to explore the expression and potential changes of immune checkpoint molecules TIGIT, CD226 and CD155 in PE patients. Methods The expression of the… read more here.
Keywords: immune checkpoint; tigit cd226; cd226 cd155; checkpoint molecules ... See more keywords
Co-expression patterns of immune checkpoint molecules in relation to PD-L1 expression.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.12113
Abstract: 12113Background: Targeting immune checkpoints has led to clinical benefit across a variety of tumor types, and employing combinations has enhanced response rates even further. We hypothesize that p... read more here.
Keywords: immune checkpoint; molecules relation; checkpoint molecules; expression patterns ... See more keywords
Mechanisms and therapeutic strategies of immune checkpoint molecules and regulators in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1090842
Abstract: Background Considered a significant risk to health and survival, type 1 diabetes (T1D) is a heterogeneous autoimmune disease characterized by hyperglycemia caused by an absolute deficiency of insulin, which is mainly due to the immune-mediated… read more here.
Keywords: immune checkpoint; checkpoint; t1d; type diabetes ... See more keywords