Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex-vivo targeting immune checkpoint molecules.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2019.05.026
Abstract: BACKGROUND & AIMS Cholangiocarcinoma is an aggressive hepatobiliary malignancy originating from biliary tract epithelium. Whether cholangiocarcinoma is responsive to immune checkpoint antibody therapy is unknown, and knowledge of its tumor immune microenvironment is limited. We… read more here.
Keywords: immune checkpoint; microenvironment; checkpoint molecules; cholangiocarcinoma ... See more keywords
Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00348-8
Abstract: Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that… read more here.
Keywords: cancer; immune checkpoint; cancer immunotherapy; checkpoint molecules ... See more keywords
Various checkpoint molecules, and tumor-infiltrating lymphocytes in common pediatric solid tumors: Possibilities for novel immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Hematology and Oncology"
DOI: 10.1080/08880018.2019.1578843
Abstract: Abstract Long-term survival rates for pediatric patients with cancer have significantly improved, but novel approaches are desired for those with refractory/relapsed solid tumors. Recently, programed cell death-1/programed cell death-ligand-1 blockade has emerged as an effective… read more here.
Keywords: pediatric solid; solid tumors; checkpoint molecules; herpes virus ... See more keywords
Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Oncoimmunology"
DOI: 10.1080/2162402x.2019.1708064
Abstract: ABSTRACT The immune checkpoint blockade (ICB) immunotherapy has prolonged overall survival for cancer patients but the response rates are low. The resistance to ICB is likely due to compensatory upregulation of additional immune inhibitory molecules.… read more here.
Keywords: checkpoint; molecules coordinately; cd8 cells; checkpoint molecules ... See more keywords
Next generation of immune checkpoint molecules in maternal-fetal immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Immunological reviews"
DOI: 10.1111/imr.13073
Abstract: Successful pregnancy is a unique situation requires the maternal immune system to recognize and tolerate a semi-identical fetus and allow normal invasion of trophoblast cells. Although efforts have been made, the deep mechanisms of the… read more here.
Keywords: immune checkpoint; next generation; pregnancy; maternal fetal ... See more keywords
Abstract 5540: Clinical significance of soluble forms of immune checkpoint molecules in advanced esophageal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5540
Abstract: Background: Immune checkpoint molecules such as PDL1 and CD155 are expressed on cancer cells and regulate tumor immunity by binding to ligands on immune cells. Although soluble forms of immune checkpoint molecules have been detected… read more here.
Keywords: esophageal cancer; immune checkpoint; checkpoint molecules; advanced esophageal ... See more keywords
Multiorgan Signaling Mobilizes Tumor-Associated Erythroid Cells Expressing Immune Checkpoint Molecules
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-20-0746
Abstract: Hematopoietic-derived cells are integral components of the tumor microenvironment and serve as critical mediators of tumor–host interactions. Host cells derived from myeloid and lymphoid lineages perform well-established functions linked to cancer development, progression, and response… read more here.
Keywords: multiorgan signaling; immune checkpoint; checkpoint molecules; cancer ... See more keywords
Co-expression patterns of immune checkpoint molecules in relation to PD-L1 expression.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.12113
Abstract: 12113Background: Targeting immune checkpoints has led to clinical benefit across a variety of tumor types, and employing combinations has enhanced response rates even further. We hypothesize that p... read more here.
Keywords: immune checkpoint; molecules relation; checkpoint molecules; expression patterns ... See more keywords
Mechanisms and therapeutic strategies of immune checkpoint molecules and regulators in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.1090842
Abstract: Background Considered a significant risk to health and survival, type 1 diabetes (T1D) is a heterogeneous autoimmune disease characterized by hyperglycemia caused by an absolute deficiency of insulin, which is mainly due to the immune-mediated… read more here.
Keywords: immune checkpoint; checkpoint; t1d; type diabetes ... See more keywords
The Role of Immune Checkpoint Molecules on Macrophages in Cancer, Infection, and Autoimmune Pathologies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.837645
Abstract: Immune checkpoint inhibitors have revolutionized immunotherapy against various cancers over the last decade. The use of checkpoint inhibitors results in remarkable re-activation of patients’ immune system, but is also associated with significant adverse events. In… read more here.
Keywords: macrophage; checkpoint; immune checkpoint; checkpoint molecules ... See more keywords
Immune checkpoint molecules in prevention and development of asthma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1070779
Abstract: Allergic asthma is a respiratory disease initiated by type-2 immune responses characterized by secretion of alarmins, interleukin-4 (IL-4), IL-5, and IL-13, eosinophilic inflammation, and airway hyperresponsiveness (AHR). Immune checkpoints (ICPs) are inhibitory or stimulatory molecules… read more here.
Keywords: immune checkpoint; prevention; development; asthma ... See more keywords