Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma
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DOI: 10.1038/s41598-020-60440-5
Abstract: In hepatocellular carcinoma (HCC), the clinical significance of soluble immune checkpoint protein levels as predictors of patient outcomes or therapeutic responses has yet to be defined. This study profiled the baseline levels of sixteen soluble… read more here.
Keywords: hepatocellular carcinoma; checkpoint proteins; soluble immune; checkpoint ... See more keywords
Monitoring Circulating Immune Checkpoint Proteins as Predictors of Non-AIDS Morbid Events in People With HIV Initiating Antiretroviral Therapy
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DOI: 10.1093/ofid/ofab570
Abstract: Abstract Background Although cell surface immune checkpoint proteins (ICPs) such as PD-1 expressed on T cells are associated with T-cell exhaustion, HIV disease progression, and AIDS events, they have shown limited utility in predicting non-AIDS… read more here.
Keywords: pre event; aids events; immune checkpoint; checkpoint proteins ... See more keywords
NRF2 Serves A Critical Role In Regulation Of Immune Checkpoint Proteins (ICPs) During Trophoblast Differentiation.
Sign Up to like & getrecommendations! Published in 2022 at "Endocrinology"
DOI: 10.1210/endocr/bqac070
Abstract: Using cultured human trophoblast stem cells (hTSCs), mid-gestation human trophoblasts in primary culture, and gene-targeted mice, we tested the hypothesis that the multinucleated syncytiotrophoblast (SynT) serves a critical role in pregnancy maintenance through production of… read more here.
Keywords: proteins icps; checkpoint proteins; serves critical; nrf2 serves ... See more keywords
POLE and Mismatch Repair Status, Checkpoint Proteins and Tumor-Infiltrating Lymphocytes in Combination, and Tumor Differentiation: Identify Endometrial Cancers for Immunotherapy
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DOI: 10.3389/fonc.2021.640018
Abstract: Objective Although Polymerase-epsilon (POLE)-mutated and mismatch repair (MMR)-deficient endometrial cancers (ECs) are considered as promising candidates for anti-PD-1/PD-L1 therapy, selecting only these patients may exclude other patients who could potentially respond to this treatment strategy,… read more here.
Keywords: combination; checkpoint proteins; tumor infiltrating; checkpoint ... See more keywords
Micromanaging checkpoint proteins
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DOI: 10.7554/elife.25001
Abstract: The kinase Mps1, long known to be the ‘boss’ in mitotic checkpoint signaling, phosphorylates multiple proteins in the checkpoint signaling cascade. read more here.
Keywords: micromanaging checkpoint; checkpoint proteins; checkpoint;