Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-021-00329-8
Abstract: Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations.… read more here.
Keywords: recovery pathway; dna repair; checkpoint recovery; instability ... See more keywords
Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05639-x
Abstract: Checkpoint recovery, the process that checkpoint-arrested cells with normal DNA repair capacity resume cell cycle progression, is essential for genome stability. However, the signaling network of the process has not been clearly defined. Here, we… read more here.
Keywords: checkpoint recovery; dna damage; biology;
PHF6 promotes non‐homologous end joining and G2 checkpoint recovery
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Reports"
DOI: 10.15252/embr.201948460
Abstract: The cellular response to DNA breaks is influenced by chromatin compaction. To identify chromatin regulators involved in the DNA damage response, we screened for genes that affect recovery following DNA damage using an RNAi library… read more here.
Keywords: end joining; recovery; dna; homologous end ... See more keywords