Functional interplay between the oxidative stress response and DNA damage checkpoint signaling for genome maintenance in aerobic organisms
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Microbiology"
DOI: 10.1007/s12275-020-9520-x
Abstract: The DNA damage checkpoint signaling pathway is a highly conserved surveillance mechanism that ensures genome integrity by sequential activation of protein kinase cascades. In mammals, the main pathway is orchestrated by two central sensor kinases,… read more here.
Keywords: dna damage; checkpoint signaling; damage checkpoint; dna ... See more keywords
Smc5/6 Complex Promotes Rad3ATR Checkpoint Signaling at the Perturbed Replication Fork through Sumoylation of the RecQ Helicase Rqh1
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DOI: 10.1128/mcb.00045-22
Abstract: Smc5/6, like cohesin and condensin, is a structural maintenance of chromosomes complex crucial for genome stability. Unlike cohesin and condensin, Smc5/6 carries an essential Nse2 subunit with SUMO E3 ligase activity. ABSTRACT Smc5/6, like cohesin… read more here.
Keywords: sumoylation; replication; checkpoint signaling; rqh1 ... See more keywords