Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.068
Abstract: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival upon anti-PD1… read more here.
Keywords: checkpoint therapy; glycolysis preserves; glycolysis; effector functions ... See more keywords
Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004803
Abstract: Purpose Checkpoint therapy is now the cornerstone of treatment for patients with renal cell carcinoma (RCC) with advanced disease, but biomarkers are lacking to predict which patients will benefit. This study proposes potential immunological biomarkers… read more here.
Keywords: checkpoint; cell; checkpoint therapy; cd8 cells ... See more keywords
Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005837
Abstract: Background The presence of a highly immunosuppressive tumor microenvironment has limited the success of immune checkpoint therapy (ICT). Immune suppressing myeloid cells with increased production of reactive oxygen species are critical drivers of this immunosuppressive… read more here.
Keywords: immune checkpoint; melanoma; checkpoint therapy; myeloid cells ... See more keywords
Impact of Chemical-Induced Mutational Load Increase on Immune Checkpoint Therapy in Poorly Responsive Murine Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-1091
Abstract: A recurring historic finding in cancer drug development is encouraging antitumor effects observed in tumor-bearing mice that fail to translate into the clinic. An intriguing exception to this pattern is immune checkpoint therapy, as the… read more here.
Keywords: immune checkpoint; checkpoint therapy; mutational load; cancer ... See more keywords
Abstract PL01-02: Immune checkpoint therapy: From CTLA-4 to PD-1/PD-L1 and beyond
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-pl01-02
Abstract: Immune checkpoint therapies, including anti-CTLA-4, anti-PD-1, and anti-PD-L1, have led to significant clinical responses in cancer patients. However, there are still substantial numbers of patients who do not respond to anti-CTLA-4 or anti-PD-1/PD-L1. We and… read more here.
Keywords: immune checkpoint; checkpoint therapy; therapy ctla; checkpoint ... See more keywords
BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-21-0129
Abstract: The authors show that tumor-specific T cells upregulate and require the transcriptional regulator BHLHE40 for tumor microenvironment remodeling and effective immune checkpoint therapy. BHLHE40 is a potential biomarker for immune checkpoint therapy efficacy and possible… read more here.
Keywords: bhlhe40; tumor; checkpoint therapy; immune checkpoint ... See more keywords
Mutation burden as a biomarker of response to immune checkpoint therapy in nine solid cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.7_suppl.35
Abstract: 35Background: A high mutation burden a biomarker of response to immune checkpoint therapy in melanoma, non-small cell lung cancer, and colorectal cancer. It is unknown whether mutation burden is predictive of response in other cancer… read more here.
Keywords: immune checkpoint; checkpoint therapy; response; cancer ... See more keywords
Combinatorial biomarkers to predict responses to immune checkpoint therapy in metastatic urothelial cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.488
Abstract: 488Background: Immune checkpoint therapy can produce durable anti-tumor responses in metastatic urothelial carcinoma (mUCC); however, the responses are not universal. Despite multiple approvals of ... read more here.
Keywords: immune checkpoint; checkpoint therapy; combinatorial biomarkers; metastatic urothelial ... See more keywords
PD-1 N58-Glycosylation-Dependent Binding of Monoclonal Antibody Cemiplimab for Immune Checkpoint Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.826045
Abstract: Immune checkpoint therapy (ICT) with a monoclonal antibody (MAb) against programmed cell death protein 1 (PD-1) is a powerful clinical treatment for tumors. Cemiplimab is a human IgG4 antibody approved in 2018 and is the… read more here.
Keywords: immune checkpoint; n58 glycosylation; checkpoint therapy; glycosylation ... See more keywords
Sequential Treatment With Targeted and Immune Checkpoint Therapy in Patients With BRAF Positive Metastatic Melanoma: The Importance of Timing?
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2019.00257
Abstract: Background: Immune checkpoint- and targeted therapy have dramatically improved the therapeutic landscape in the management of BRAF mutation positive metastatic melanoma. However, pending the results of clinical trials, not only is it currently unclear whether… read more here.
Keywords: therapy; immune checkpoint; checkpoint therapy; metastatic melanoma ... See more keywords
Quantifying PD-L1 Expression to Monitor Immune Checkpoint Therapy: Opportunities and Challenges
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12113173
Abstract: Simple Summary Malignant cells hijack the regulatory roles of immune checkpoint proteins for immune evasion and survival. Therapeutics blocking those proteins can restore the balance of the immune system and lead to durable responses in… read more here.
Keywords: immune checkpoint; checkpoint therapy; quantifying expression; checkpoint ... See more keywords