Boosting Immune Checkpoint Therapy Efficacy of Pancreatic Cancer by Cell‐Anchoring Probiotic
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202502197
Abstract: Live bacteria in tumor sites can recruit and activate T cells, enhancing the efficacy of immune checkpoint therapy (ICT) for cancer. However, the low bacterial presence within tumors may insufficiently trigger ICT. Here bio‐orthogonal click… read more here.
Keywords: cancer; immune checkpoint; cell; pancreatic cancer ... See more keywords
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.068
Abstract: Tumor-derived lactic acid inhibits T and natural killer (NK) cell function and, thereby, tumor immunosurveillance. Here, we report that melanoma patients with high expression of glycolysis-related genes show a worse progression free survival upon anti-PD1… read more here.
Keywords: checkpoint therapy; glycolysis preserves; glycolysis; effector functions ... See more keywords
Programmable engineered bacteria as sustained-releasing antibody factory in situ for enhancing tumor immune checkpoint therapy
Sign Up to like & getrecommendations! Published in 2025 at "Science Advances"
DOI: 10.1126/sciadv.adt7298
Abstract: Tumor immune checkpoint therapy (ICT) aims to block immune escape signals between tumor and immune cells. However, low delivery efficiency of immune checkpoint inhibitors (ICIs), narrow single-target approach, and reduced responsiveness notably hinder clinical development… read more here.
Keywords: tumor immune; immune checkpoint; macrophage; tumor ... See more keywords
Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004803
Abstract: Purpose Checkpoint therapy is now the cornerstone of treatment for patients with renal cell carcinoma (RCC) with advanced disease, but biomarkers are lacking to predict which patients will benefit. This study proposes potential immunological biomarkers… read more here.
Keywords: checkpoint; cell; checkpoint therapy; cd8 cells ... See more keywords
Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005837
Abstract: Background The presence of a highly immunosuppressive tumor microenvironment has limited the success of immune checkpoint therapy (ICT). Immune suppressing myeloid cells with increased production of reactive oxygen species are critical drivers of this immunosuppressive… read more here.
Keywords: immune checkpoint; melanoma; checkpoint therapy; myeloid cells ... See more keywords
Why has immune “checkpoint” therapy failed in most clinical trials?
Sign Up to like & getrecommendations! Published in 2025 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2025-012457
Abstract: Cancer immunotherapy targeting the PD-1/PD-L1 pathway has demonstrated efficacy across a range of common solid tumors and some hematopoietic malignancies. Despite these groundbreaking successes, the clinical development of other ‘checkpoint inhibitors’ targeting molecules like TIM-3,… read more here.
Keywords: therapy failed; therapy; immune checkpoint; failed clinical ... See more keywords
Impact of Chemical-Induced Mutational Load Increase on Immune Checkpoint Therapy in Poorly Responsive Murine Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-17-1091
Abstract: A recurring historic finding in cancer drug development is encouraging antitumor effects observed in tumor-bearing mice that fail to translate into the clinic. An intriguing exception to this pattern is immune checkpoint therapy, as the… read more here.
Keywords: immune checkpoint; checkpoint therapy; mutational load; cancer ... See more keywords
Abstract PL01-02: Immune checkpoint therapy: From CTLA-4 to PD-1/PD-L1 and beyond
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-pl01-02
Abstract: Immune checkpoint therapies, including anti-CTLA-4, anti-PD-1, and anti-PD-L1, have led to significant clinical responses in cancer patients. However, there are still substantial numbers of patients who do not respond to anti-CTLA-4 or anti-PD-1/PD-L1. We and… read more here.
Keywords: immune checkpoint; checkpoint therapy; therapy ctla; checkpoint ... See more keywords
BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy
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DOI: 10.1158/2326-6066.cir-21-0129
Abstract: The authors show that tumor-specific T cells upregulate and require the transcriptional regulator BHLHE40 for tumor microenvironment remodeling and effective immune checkpoint therapy. BHLHE40 is a potential biomarker for immune checkpoint therapy efficacy and possible… read more here.
Keywords: bhlhe40; tumor; checkpoint therapy; immune checkpoint ... See more keywords
Mutation burden as a biomarker of response to immune checkpoint therapy in nine solid cancers.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.7_suppl.35
Abstract: 35Background: A high mutation burden a biomarker of response to immune checkpoint therapy in melanoma, non-small cell lung cancer, and colorectal cancer. It is unknown whether mutation burden is predictive of response in other cancer… read more here.
Keywords: immune checkpoint; checkpoint therapy; response; cancer ... See more keywords
Combinatorial biomarkers to predict responses to immune checkpoint therapy in metastatic urothelial cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.6_suppl.488
Abstract: 488Background: Immune checkpoint therapy can produce durable anti-tumor responses in metastatic urothelial carcinoma (mUCC); however, the responses are not universal. Despite multiple approvals of ... read more here.
Keywords: immune checkpoint; checkpoint therapy; combinatorial biomarkers; metastatic urothelial ... See more keywords