Articles with "chelator pbt2" as a keyword



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Chelator PBT2 Forms a Ternary Cu2+ Complex with β-Amyloid That Has High Stability but Low Specificity

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Published in 2023 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms24119267

Abstract: The metal chelator PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) acts as a terdentate ligand capable of forming binary and ternary Cu2+ complexes. It was clinically trialed as an Alzheimer’s disease (AD) therapy but failed to progress beyond phase II.… read more here.

Keywords: high stability; pbt2; chelator pbt2; ternary cu2 ... See more keywords