Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells
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DOI: 10.1038/s41598-017-02222-0
Abstract: Triple-negative breast cancer (TNBC) is a subtype of breast cancer lacking targeted therapy currently. Recent studies imply that protein kinase C may play important roles in TNBC development and could be a specific target. In… read more here.
Keywords: cell lines; tnbc; chelerythrine; breast cancer ... See more keywords
Inhibitors Targeting Multiple Janus Kinases From Zanthoxylum simulans Mediate Inhibition and Apoptosis Against Gastric Cancer Cells via the Estrogen Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.922110
Abstract: Janus kinases (JAKs) play a key role in subtly regulating proliferation, apoptosis, and differentiation of cancer cells, and their inhibitors are actively sought as new drug leads. By developing JAKs based affinity ultrafiltration method coupled… read more here.
Keywords: cancer cells; apoptosis; chelerythrine; gastric cancer ... See more keywords
Metabolism and Tissue Distribution of Chelerythrine and Effects of Macleaya Cordata Extracts on Liver NAD(P)H Quinone Oxidoreductase
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DOI: 10.3389/fvets.2021.659771
Abstract: Background: Macleaya cordata (Willd.) (Papaveraceae) is listed as a feed additive in animal production by the European Food Authority. Methods: The metabolites of chelerythrine in rats were measured in vitro and in vivo by rapid… read more here.
Keywords: reduction; tissue distribution; chelerythrine; cordata extracts ... See more keywords
Efficacy of Chelerythrine Against Mono- and Dual-Species Biofilms of Candida albicans and Staphylococcus aureus and Its Properties of Inducing Hypha-to-Yeast Transition of C. albicans
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DOI: 10.3390/jof6020045
Abstract: Candida albicans and Staphylococcus aureus specifically often resulted in biofilm-associated diseases, ranging from superficial mucosal to life-threatening systemic infections. Recent studies reported that chelerythrine displayed antimicrobial activities against a few microorganisms, but its effects on… read more here.
Keywords: species biofilms; albicans staphylococcus; chelerythrine; candida albicans ... See more keywords