Epithelial chemerin–CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205574119
Abstract: Significance Epithelial antimicrobial defense is an important innate mechanism to maintain intestinal homeostasis and closely involved in the pathogenesis of inflammatory bowel disease (IBD). Chemerin, which is abundantly expressed in barrier tissues, regulates tissue inflammation… read more here.
Keywords: chemerin cmklr1; chemerin; cmklr1 signaling; microbiota driven ... See more keywords
Chemerin/CMKLR1 Axis Promotes the Progression of Proliferative Diabetic Retinopathy
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DOI: 10.1155/2021/4468625
Abstract: Background Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes, and the levels of chemerin were associated with the severity of DR. However, there is no research on chemerin in the development of proliferative… read more here.
Keywords: chemerin cmklr1; chemerin; diabetic retinopathy; pdr ... See more keywords
Targeting the chemerin/CMKLR1 axis by small molecule antagonist α-NETA mitigates endometriosis progression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.985618
Abstract: Endometriosis is a common gynecological disease, characterized by the presence of endometrial-like lesions outside the uterus. This debilitating disease causes chronic pelvic pain and infertility with limited therapeutics. Chemerin is a secretory protein that acts… read more here.
Keywords: cmklr1 axis; small molecule; molecule antagonist; endometriosis ... See more keywords
Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender
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DOI: 10.3390/ijms19102905
Abstract: Chemerin (also known as tazarotene-induced gene 2 and retinoic acid receptor responder 2) has been identified as an adipokine that exerts effects on many biological processes, including adipogenesis, angiogenesis, inflammation, immune responses, and food intake.… read more here.
Keywords: cmklr1; chemerin cmklr1; nutritional status; expression ... See more keywords
Simvastatin inhibits the adipogenesis of bone marrow-derived mesenchymal stem cells through the downregulation of chemerin/CMKLR1 signaling
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2020.4606
Abstract: Simvastatin is effective in the treatment of osteoporosis, partly through the inhibition of the adipogenesis of bone-marrow derived mesenchymal stem cells (BMSCs). The present study focused on the mechanisms responsible for the inhibitory effects of… read more here.
Keywords: cmklr1 signaling; cmklr1; chemerin cmklr1; adipogenesis ... See more keywords