CDK4/6 inhibitor protects chemerin‐induced human granulosa‐lutein cells from apoptosis by inhibiting the p53/p21 waf pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23241
Abstract: Dysregulation of the cell cycle is common in human tumorigenesis. Therefore, CDK4/6 inhibitors targeting the cell cycle have been developed, and their antiapoptotic effects have been highly correlated with potential clinical therapies. The aim of… read more here.
Keywords: cdk4 inhibitor; hgl cells; chemerin induced; granulosa lutein ... See more keywords
Chemerin-induced arterial contraction is Gi- and calcium-dependent.
Sign Up to like & getrecommendations! Published in 2017 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2016.11.009
Abstract: Chemerin is an adipokine associated with increased blood pressure, and may link obesity with hypertension. We tested the hypothesis that chemerin-induced contraction of the vasculature occurs via calcium flux in smooth muscle cells. Isometric contraction… read more here.
Keywords: inhibitor; chemerin induced; contraction; smooth muscle ... See more keywords