6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and small chemical activators affect enzyme activity of activating glucokinase mutants by distinct mechanisms.
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DOI: 10.1016/j.bcp.2019.06.024
Abstract: Glucokinase (GK), a monomeric glucose-phosphorylating enzyme characterised by high structural flexibility, acts as a glucose sensor in pancreatic beta cells and liver. Pharmaceutical efforts to control the enzyme are hampered by an incomplete understanding of… read more here.
Keywords: glucokinase; fbpase; phosphofructo kinase; chemical activators ... See more keywords