Coomassie brilliant blue G-250 acts as a potential chemical chaperone to stabilize therapeutic insulin
Sign Up to like & getrecommendations! Published in 2023 at "Chemical Communications"
DOI: 10.1039/d3cc01791e
Abstract: Our studies show Coomassie Brilliant Blue G-250 as a promising chemical chaperone that stabilises the α-helical native human insulin conformers, disrupting their aggregation. Furthermore, it also increases the insulin secretion. This multipolar effect coupled with… read more here.
Keywords: chemical chaperone; blue 250; coomassie brilliant; chemical ... See more keywords
Ameliorating the Metabolic Burden of the Co-expression of Secreted Fungal Cellulases in a High Lipid-Accumulating Yarrowia lipolytica Strain by Medium C/N Ratio and a Chemical Chaperone
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DOI: 10.3389/fmicb.2018.03276
Abstract: Yarrowia lipolytica, known to accumulate lipids intracellularly, lacks the cellulolytic enzymes needed to break down solid biomass directly. This study aimed to evaluate the potential metabolic burden of expressing core cellulolytic enzymes in an engineered… read more here.
Keywords: high lipid; chemical chaperone; expression; metabolic burden ... See more keywords
Quantification of the Chemical Chaperone 4-Phenylbutyric Acid (4-PBA) in Cell Culture Media via LC-HRMS: Applications in Fields of Neurodegeneration and Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16020298
Abstract: In recent years, 4-phenylbutyric acid (4-PBA), an FDA-approved drug, has increasingly been used as a nonspecific chemical chaperone in vitro and in vitro, but its pharmacodynamics is still not clear. In this context, we developed… read more here.
Keywords: acid pba; cell; chemical chaperone; acid ... See more keywords