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Published in 2020 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2020.01.005
Abstract: Parkinson's disease (PD) is characterized by progressive loss of dopaminergic neurons and the accumulation of deposits of α-synuclein (α-syn) in the brain. The pivotal role of α-syn aggregation in PD makes it an attractive target…
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Keywords:
disease;
chaperones novel;
novel drugs;
drugs parkinson ... See more keywords
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Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s393816
Abstract: Abstract The endoplasmic reticulum (ER) is responsible for structural transformation or folding of de novo proteins for transport to the Golgi. When the folding capacity of the ER is exceeded or excessive accumulation of misfolded…
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Keywords:
endoplasmic reticulum;
stress;
chaperones inhibit;
chemical chaperones ... See more keywords
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Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11135762
Abstract: (1) Background: Congenital factor (F) VII deficiency is caused by mutations in the F7 gene. Patients with modest differences in FVII levels may display large differences in clinical severity. The variant p.A354V-p.P464Hfs is associated with…
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Keywords:
factor vii;
a354v p464hfs;
variant;
variant a354v ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25214904
Abstract: Accumulation of misfolded and mistrafficked rhodopsin on the endoplasmic reticulum of photoreceptor cells has a pivotal role in the pathogenesis of retinitis pigmentosa and a subset of Leber’s congenital amaurosis. One potential strategy to reduce…
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Keywords:
cis retinal;
rhodopsin;
binding compounds;
computational studies ... See more keywords
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Published in 2019 at "eLife"
DOI: 10.7554/elife.43302
Abstract: The endoplasmic reticulum (ER) is responsible for folding secretory and membrane proteins, but disturbed ER proteostasis may lead to protein aggregation and subsequent cellular and clinical pathologies. Chemical chaperones have recently emerged as a potential…
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Keywords:
protein aggregation;
based hts;
cell based;
chemical chaperones ... See more keywords