Prospective computational design and in vitro bio-analytical tests of new chemical entities as potential selective CYP17A1 lyase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103462
Abstract: The development and advancement of prostate cancer (PCa) into stage 4, where it metastasize, is a major problem mostly in elder males. The growth of PCa cells is stirred up by androgens and androgen receptor… read more here.
Keywords: new chemical; selective cyp17a1; prospective computational; chemical entities ... See more keywords
Experimentally Validated Pharmacoinformatics Approach to Predict hERG Inhibition Potential of New Chemical Entities
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.01035
Abstract: The hERG (human ether-a-go-go-related gene) encoded potassium ion (K+) channel plays a major role in cardiac repolarization. Drug-induced blockade of hERG has been a major cause of potentially lethal ventricular tachycardia termed Torsades de Pointes… read more here.
Keywords: herg inhibition; new chemical; chemical entities; inhibition potential ... See more keywords
A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1119607
Abstract: Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system. When these essential… read more here.
Keywords: cell based; entities reverse; immune escape; metastatic tumours ... See more keywords
A Novel Reagent for Radioiodine Labeling of New Chemical Entities (NCEs) and Biomolecules
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26144344
Abstract: Radioiodine labeling of peptides and proteins is routinely performed by using various oxidizing agents such as Chloramine T, Iodobeads, and Iodogen reagent and radioactive iodide (I−), although some other oxidizing agents were also investigated. The… read more here.
Keywords: novel reagent; radioiodine labeling; new chemical; radioiodine ... See more keywords