Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis
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DOI: 10.1038/s41467-020-17027-5
Abstract: Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous… read more here.
Keywords: genetics; chemical genetics; target; strategy ... See more keywords
Plants and Small Molecules: An Up-and-Coming Synergy
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DOI: 10.3390/plants12081729
Abstract: The emergence of Arabidopsis thaliana as a model system has led to a rapid and wide improvement in molecular genetics techniques for studying gene function and regulation. However, there are still several drawbacks that cannot… read more here.
Keywords: plants small; coming synergy; chemical genetics; small molecules ... See more keywords