Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600134
Abstract: Detecting and interpreting extracellular spatial signals is essential for cellular orientation within complex environments, such as during directed cell migration or growth in multicellular development. Although the molecular understanding of how cells read spatial signals… read more here.
Keywords: chemical gradients; sampling paints; local concentration; local sampling ... See more keywords
Investigating protein translocation in the presence of an electrolyte concentration gradient across a solid‐state nanopore
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202100346
Abstract: Electrolyte chemistry plays an important role in the transport properties of analytes through nanopores. Here, we report the translocation properties of the protein human serum transferrin (hSTf) in asymmetric LiCl salt concentrations with either positive… read more here.
Keywords: investigating protein; concentration; protein translocation; chemical gradients ... See more keywords
A web-based application for automated quantification of chemical gradients induced in microfluidic devices
Sign Up to like & getrecommendations! Published in 2018 at "Computers in biology and medicine"
DOI: 10.1016/j.compbiomed.2018.02.001
Abstract: Advances in microfabrication have allowed the development and popularization of microfluidic devices, which are powerful tools to recreate three-dimensional (3-D) biologically relevant in vitro models. These microenvironments are usually generated by using hydrogels and induced… read more here.
Keywords: web based; microfluidic devices; chemical; chemical gradients ... See more keywords
Photopatterned Membranes and Chemical Gradients Enable Scalable Phenotypic Organization of Primary Human Colon Epithelial Models.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b04217
Abstract: Biochemical gradients across the intestinal epithelium play a major role in governing intestinal stem cell compartmentalization, differentiation dynamics, and organ-level self-renewal. However, scalable platforms that recapitulate the architecture and gradients present in vivo are absent.… read more here.
Keywords: phenotypic; photopatterned membranes; chemical gradients; membranes chemical ... See more keywords
Steering particles via micro-actuation of chemical gradients using model predictive control.
Sign Up to like & getrecommendations! Published in 2023 at "Biomicrofluidics"
DOI: 10.1063/5.0126690
Abstract: Biological systems rely on chemical gradients to direct motion through both chemotaxis and signaling, but synthetic approaches for doing the same are still relatively naïve. Consequently, we present a novel method for using chemical gradients… read more here.
Keywords: control; chemical gradients; particles via; model ... See more keywords