Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2256-2
Abstract: The utilisation of genome-wide transcriptomics has played a pivotal role in advancing the field of toxicology, allowing the mapping of transcriptional signatures to chemical exposures. These activities have uncovered several transcriptionally regulated pathways that can… read more here.
Keywords: tempo seq; chemical induced; rptec tert1; induced transcriptomic ... See more keywords
Chemical induced pathognomonic features observed in human vitiligo are mediated through miR-2909 RNomics pathway.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2020.06.004
Abstract: BACKGROUND Chemicals like Monobenzyl Ether of Hydroquinone (MBEH) and 4-Tertiary Butyl Phenol (4-TBP) have been widely recognized to induce clinical lesions that resemble vitiligo, but exact molecular pathway through which these chemicals initiate vitiligo is… read more here.
Keywords: vitiligo; chemical induced; pathognomonic features; induced pathognomonic ... See more keywords
Comparison of Chemical-Induced Fracturing by Na2S2O8, NaClO, and H2O2 in Marcellus Shale
Sign Up to like & getrecommendations! Published in 2020 at "Energy & Fuels"
DOI: 10.1021/acs.energyfuels.0c02623
Abstract: Shale–oxidant reactions can enhance the permeability of organic-rich shale reservoirs through chemical-induced fracturing. Choosing the best oxidant for this purpose is explored in this study. To c... read more here.
Keywords: fracturing na2s2o8; chemical induced; induced fracturing; na2s2o8 naclo ... See more keywords
Profiling Secreted miRNA Biomarkers of Chemical-Induced Neurodegeneration in Human iPSC-Derived Neurons
Sign Up to like & getrecommendations! Published in 2022 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfac011
Abstract: Abstract Elucidation of predictive fluidic biochemical markers to detect and monitor chemical-induced neurodegeneration has been a major challenge due to a lack of understanding of molecular mechanisms driving altered neuronal morphology and function, as well… read more here.
Keywords: derived neurons; chemical induced; biomarkers chemical; induced neurodegeneration ... See more keywords
Chemical-induced disease extraction via recurrent piecewise convolutional neural networks
Sign Up to like & getrecommendations! Published in 2018 at "BMC Medical Informatics and Decision Making"
DOI: 10.1186/s12911-018-0629-3
Abstract: BackgroundExtracting relationships between chemicals and diseases from unstructured literature have attracted plenty of attention since the relationships are very useful for a large number of biomedical applications such as drug repositioning and pharmacovigilance. A number… read more here.
Keywords: extraction; chemical induced; induced disease; piecewise ... See more keywords
A targeted gene expression platform allows for rapid analysis of chemical-induced antioxidant mRNA expression in zebrafish larvae
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0171025
Abstract: Chemical-induced oxidative stress and the biochemical pathways that protect against oxidative damage are of particular interest in the field of toxicology. To rapidly identify oxidative stress-responsive gene expression changes in zebrafish, we developed a targeted… read more here.
Keywords: chemical induced; analysis; platform; expression ... See more keywords
XML-CIMT: Explainable Machine Learning (XML) Model for Predicting Chemical-Induced Mitochondrial Toxicity
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415655
Abstract: Organ toxicity caused by chemicals is a serious problem in the creation and usage of chemicals such as medications, insecticides, chemical products, and cosmetics. In recent decades, the initiation and development of chemical-induced organ damage… read more here.
Keywords: chemical induced; mitochondrial toxicity; induced mitochondrial; toxicity ... See more keywords
Combined use of alcohol in conventional chemical-induced mouse liver cancer model improves the simulation of clinical characteristics of human hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncology Letters"
DOI: 10.3892/ol.2017.6800
Abstract: Liver cancer is the one of most common types of cancer and the 2nd cause of cancer-associated mortalities worldwide. Establishing appropriate animal models of liver cancer is essential for basic and translational studies. The present… read more here.
Keywords: chemical induced; conventional chemical; model; cancer ... See more keywords
Synovial fluid proteome profile of surgical versus chemical induced osteoarthritis in rabbits
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.12897
Abstract: Background Animal models are significant for understanding human osteoarthritis (OA). This study compared the synovial fluid proteomics changes in surgical and chemical induced OA models. Methods Thirty rabbits either had anterior cruciate ligament transection (ACLT)… read more here.
Keywords: chemical induced; induced joints; proteome profile; chemical ... See more keywords