Psoralen as an interstrand DNA crosslinker in the selection of DNA-Encoded dynamic chemical library.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.04.033
Abstract: DNA-encoded chemical library (DEL) has emerged as a powerful technology for ligand discovery in biomedical research. Recently, we have developed a DNA-encoded dynamic library (DEDL) approach by incorporating the concept of dynamic combinatorial library (DCL)… read more here.
Keywords: chemical library; interstrand dna; dna; dna encoded ... See more keywords
Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.04.007
Abstract: Pharmacophore-focused chemical libraries are continuously being created in drug discovery programs, yet screening assays to maximize the usage of such libraries are not fully explored. Here, we report a chemical proteomics approach to reutilizing a… read more here.
Keywords: chemical library; focused chemical; chemoproteomic profiling; pharmacophore focused ... See more keywords
Neuroprotective effect of an Nrf2‐ARE activator identified from a chemical library on dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.11.023
Abstract: Abstract The nuclear factor erythroid 2‐related factor 2 (Nrf2)‐antioxidant response element (ARE) pathway, which induces the production of antioxidant enzymes, is a possible therapeutic target for treating diseases related to oxidative stress. Nrf2 activators often… read more here.
Keywords: chemical library; nrf2 activator; identified chemical; effect ... See more keywords
Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00444
Abstract: Covalent conjugates of multiple nutrients often exhibit greater biological activities than each individual nutrient and more predictable safety profiles than completely unnatural chemical entities. Here we report the construction and application of a focused chemical… read more here.
Keywords: source; chemical library; molecule; energy metabolism ... See more keywords
A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b08039
Abstract: DNA-encoded chemical libraries are increasingly used in pharmaceutical research because they enable the rapid discovery of synthetic protein ligands. Here we explored whether target-class focused DNA-encoded chemical libraries can be cost-effective tools to achieve robust… read more here.
Keywords: chemical library; dna; dna encoded; focused dna ... See more keywords
Advancing ASMS with LC-MS/MS for the discovery of novel PDCL2 ligands from DNA-Encoded chemical library selections.
Sign Up to like & getrecommendations! Published in 2022 at "Andrology"
DOI: 10.1111/andr.13309
Abstract: BACKGROUND A safe, effective, and reversible nonhormonal male contraceptive drug is greatly needed for male contraception as well as for circumventing the side effects of female hormonal contraceptives. Phosducin-like 2 (PDCL2) is a testis-specific phosphoprotein… read more here.
Keywords: encoded chemical; decl; dna; chemical library ... See more keywords