Synthetic chemical ligands and cognate antibodies for biorthogonal drug targeting and cell engineering.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2021.01.010
Abstract: A vast range of biomedical applications relies on the specificity of interactions between an antigen and its cognate receptor or antibody. This specificity can be highest when said antigen is a non-natural (synthetic) molecule introduced… read more here.
Keywords: synthetic chemical; engineering; drug; chemical ligands ... See more keywords
Targeting prohibitins with chemical ligands inhibits KRAS-mediated lung tumours
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2017.93
Abstract: KRAS is one of the most frequently mutated oncogenes in human non-small cell lung cancers (NSCLCs). RAS proteins trigger multiple effector signalling pathways including the highly conserved RAF-MAPK pathway. CRAF, a direct RAS effector protein,… read more here.
Keywords: craf; targeting prohibitins; chemical ligands; prohibitins chemical ... See more keywords