Abstract 689: Identification and optimization of novel chemical matter via a structure-based approach resulting in a probe for MTH1
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DOI: 10.1158/1538-7445.am2018-689
Abstract: Cancer cells can form reactive oxygen species (ROS) due to altered redox regulation that affect desoxynucleosides triphosphates (dNTP) in particular. 8-oxo-29-deoxyguanosine-59-triphosphate (8-oxo-dGTP) and 2-hydroxydeoxyadenosine-59-triphosphate (2-OH-dATP) are the two most abundant oxidative nucleotide lesions in this… read more here.
Keywords: chemical matter; structure based; mth1; novel chemical ... See more keywords