Advancing New Chemical Modalities into Clinical Studies.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.2c00375
Abstract: Drug discovery and development has experienced an incredible paradigm shift in the past two decades. What once was considered a predominant R&D landscape of small molecules within a prescribed properties and mechanism space now includes… read more here.
Keywords: clinical studies; advancing new; modalities clinical; chemical modalities ... See more keywords
New Chemical Modalities and Strategic Thinking in Early Drug Discovery.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00582
Abstract: The classical toolbox for drug discovery is continuously expanding beyond traditional small molecules. New chemical modalities including RNA therapeutics, protein degraders, cyclopeptides, antibody drug conjugates, and gene therapy have matured, demonstrating clinical success and are… read more here.
Keywords: new chemical; modalities strategic; drug; chemical modalities ... See more keywords
Impact of Allosteric Modulation in Drug Discovery: Innovation in Emerging Chemical Modalities.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.9b00655
Abstract: Recent years have seen an unprecedented level of innovation in allosteric drug discovery and development, with multiple drug candidates advancing into clinical studies. From early examples of allosteric drugs like GABAA receptor modulators (benzodiazepines) in… read more here.
Keywords: innovation; drug; chemical modalities; drug discovery ... See more keywords