New insight on the structural features of the cytotoxic auristatins MMAE and MMAF revealed by combined NMR spectroscopy and quantum chemical modelling
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DOI: 10.1038/s41598-017-15674-1
Abstract: Antibody-drug conjugates (ADCs) are emerging as a promising class of selective drug delivery systems in the battle against cancer and other diseases. The auristatins monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) appear as… read more here.
Keywords: quantum chemical; chemical modelling; drug; spectroscopy ... See more keywords
Chemical modelling of glycolaldehyde and ethylene glycol in star-forming regions
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DOI: 10.1093/mnras/stx3335
Abstract: Glycolaldehyde (HOCH$_2$CHO) and ethylene glycol ((CH$_2$OH)$_2$) are two complex organic molecules detected in the hot cores and hot corinos of several star-forming regions. The ethylene glycol/glycolaldehyde abundance ratio seems to show an increase with the… read more here.
Keywords: star forming; forming regions; ethylene glycol; chemical modelling ... See more keywords