A molecular‐level perspective on the frequency, distribution, and consequences of messenger RNA modifications
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1586
Abstract: Cells use chemical modifications to alter the sterics, charge, and conformations of large biomolecules, modulating their biogenesis, function, and stability. Until recently post‐transcriptional RNA modifications were thought to be largely limited to nonprotein coding RNA… read more here.
Keywords: molecular level; frequency; mrna modifications; rna modifications ... See more keywords
Effect of selected physical and chemical modifications on physicochemical, pasting, and morphological properties of underutilized starch from rice bean (Vigna umbellata)
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Food Science and Technology"
DOI: 10.1007/s13197-021-04974-0
Abstract: Starch was extracted from the rice bean which is largely underutilized and modified by physical (i.e. heat moisture treatment and retrogradation) and chemical (i.e. esterification and acid alcohol modification) methods. Both, physical and chemical modifications… read more here.
Keywords: rice bean; chemical modifications; physical chemical; starch ... See more keywords
Peptaibols as a model for the insertions of chemical modifications.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.09.016
Abstract: Peptaibols are linear non ribosomal peptides which have been the object of intense research efforts regarding their synthesis and the elucidation of the mechanism allowing their insertion in biological membranes. Forty years after their discovery… read more here.
Keywords: model insertions; insertions chemical; chemical modifications; peptaibols model ... See more keywords
Reading Chemical Modifications in the Transcriptome.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.10.006
Abstract: Diverse chemical modifications have been identified in the transcriptome, leading to the emerging field of epitranscriptomics. In eukaryotic mRNA, the 5' cap and 3' poly(A) tail play important roles in regulation, and multiple internal modifications… read more here.
Keywords: modifications transcriptome; chemical modifications; biology; reading chemical ... See more keywords
Chemical modifications of globular proteins phototriggered by an endogenous photosensitizer.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00286
Abstract: The main goal of the present work was to investigate the damages photoinduced by pterin (Ptr), an endogenous photosensitizer present in human skin under pathological conditions, on a globular protein such as ubiquitin (Ub). A… read more here.
Keywords: endogenous photosensitizer; proteins phototriggered; chemical modifications; globular proteins ... See more keywords
Chemical Modifications to RNA: A New Layer of Gene Expression Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b00960
Abstract: The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 chemically distinct modifications have been identified in cellular RNA. With the recent development of novel chemical and/or biochemical… read more here.
Keywords: modifications rna; chemical; biology; chemical modifications ... See more keywords
Chemical Modifications Reduce Auditory Cell Damage Induced by Aminoglycoside Antibiotics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12420
Abstract: Although aminoglycoside antibiotics are effective against Gram-negative infections, these drugs often cause irreversible hearing damage. Binding to the decoding site of eukaryotic ribosomes appears to result in ototoxicity, but there is evidence that other effects… read more here.
Keywords: aminoglycoside antibiotics; reduce auditory; chemical modifications; auditory cell ... See more keywords
Visualization of chemical modifications in the human 80S ribosome structure
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24482
Abstract: Chemical modifications of human ribosomal RNA (rRNA) are introduced during biogenesis and have been implicated in the dysregulation of protein synthesis, as is found in cancer and other diseases. However, their role in this phenomenon… read more here.
Keywords: 80s ribosome; modifications human; chemical modifications; structure ... See more keywords
Multiple chemical modifications and Cd2+ adsorption characteristics of sludge-based activated carbon
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra03268f
Abstract: Sludge resource utilization is commonly realized through carbonization, but the use of direct carbonization to obtain sludge-based activated carbon (SAC) is not functional yet. The multiple chemical modifications were carried out to achieve N-doping and… read more here.
Keywords: 320 320; adsorption; sludge based; sacu ... See more keywords
An Overview on Exploring Chemical Modifications of Aromatic Amino Acid Residues in Peptides
Sign Up to like & getrecommendations! Published in 2023 at "Synthesis"
DOI: 10.1055/a-2091-8062
Abstract: The chemical diversification of biomolecules set forth a significant area that constitutes an important intersection between chemistry and biology. Amino acids and peptides, are the fundamental building blocks of proteins, play an ubiquitous role in… read more here.
Keywords: acid residues; amino acid; aromatic amino; chemical modifications ... See more keywords
Epitranscriptomics in parasitic protists: Role of RNA chemical modifications in posttranscriptional gene regulation
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1010972
Abstract: “Epitranscriptomics” is the new RNA code that represents an ensemble of posttranscriptional RNA chemical modifications, which can precisely coordinate gene expression and biological processes. There are several RNA base modifications, such as N6-methyladenosine (m6A), 5-methylcytosine… read more here.
Keywords: parasitic protists; regulation; gene expression; chemical modifications ... See more keywords