"Chemical modulation of gasdermin-mediated pyroptosis and therapeutic potential".
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.167183
Abstract: Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune responses and causes tissue damage. Gasdermin (GSDM) proteins are a family of pore-forming executors of pyroptosis. While the most-studied member, GSDMD, exerts critical… read more here.
Keywords: modulation gasdermin; biology; mediated pyroptosis; chemical modulation ... See more keywords
Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b00775
Abstract: In humans, peptides derived from dietary proteins and peptide-like drugs are transported via the proton-dependent oligopeptide transporter hPepT1 (SLC15A1). hPepT1 is located across the apical membranes of the small intestine and kidney, where it serves… read more here.
Keywords: oligopeptide transporter; hpept1; transporter hpept1; modulation human ... See more keywords
Selective Chemical Modulation of Interlayer Excitons in Atomically Thin Heterostructures.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.9b05254
Abstract: Strongly-bound interlayer excitons (XIs) in atomically thin transition metal dichalcogenide (TMDC) heterostructures such as MoS2/WSe2 show promising optoelectronic properties for spinvalleytronics and excitonic devices. The ability to probe and control XIs is critical for the… read more here.
Keywords: interlayer excitons; modulation interlayer; interlayer; chemical modulation ... See more keywords
Chemical Modulation of Pre-mRNA Splicing in Mammalian Systems.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00001
Abstract: RNA splicing is a key component of gene expression and proteomic diversity in humans. The spliceosome assembles on and processes individual nascent pre-mRNA transcripts into distinct mature mRNAs that can code for different proteins. Splicing… read more here.
Keywords: pre; modulation pre; mrna splicing; chemical modulation ... See more keywords
Chemical Modulation of the Human Mitochondrial ClpP: Potential Application in Cancer Therapeutics.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical biology"
DOI: 10.1021/acschembio.9b00347
Abstract: The human ClpP proteolytic complex (HsClpP) is a serine protease located in the mitochondrial matrix and participates in the maintenance of the mitochondrial proteome among other cellular functions. HsClpP typically forms a multimeric complex with… read more here.
Keywords: hsclpp; modulation human; clpp; chemical modulation ... See more keywords
Chemical modulation of SQSTM1/p62-mediated xenophagy that targets a broad range of pathogenic bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2054240
Abstract: ABSTRACT The N-degron pathway is a proteolytic system in which the N-terminal degrons (N-degrons) of proteins, such as arginine (Nt-Arg), induce the degradation of proteins and subcellular organelles via the ubiquitin-proteasome system (UPS) or macroautophagy/autophagy-lysosome… read more here.
Keywords: chemical modulation; xenophagy; sqstm1 p62; broad range ... See more keywords
Interlayer Chemical Modulation of Phase Transitions in Two-Dimensional Metal Chalcogenides
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28030959
Abstract: Two-dimensional metal chalcogenides (2D-MCs) with complex interactions are usually rich in phase transition behavior, such as superconductivity, charge density wave (CDW), and magnetic transitions, which hold great promise for the exploration of exciting physical properties… read more here.
Keywords: interlayer chemical; chemical modulation; modulation; phase transitions ... See more keywords