In Vivo Chemical Probing for G-Quadruplex Formation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9666-7_23
Abstract: While DNA inside the cells is predominantly canonical right-handed double helix, guanine-rich DNAs have potential to fold into four-stranded structures that contain stacks of G-quartets (G4 DNA quadruplex). Genome sequencing has revealed G4 sequences tend… read more here.
Keywords: methodology; chemical probing; dna; formation ... See more keywords
Chemical probing for examining the structure of modified RNAs and ligand binding to RNA.
Sign Up to like & getrecommendations! Published in 2019 at "Methods"
DOI: 10.1016/j.ymeth.2018.10.015
Abstract: Among different RNA modifications, the helix 69 (H69) region of the bacterial ribosomal RNA (rRNA) contains three pseudouridines (Ψs). H69 is functionally important due to its location in the heart of the ribosome. Several structural… read more here.
Keywords: chemical probing; probing examining; rna; examining structure ... See more keywords
Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00782
Abstract: ConspectusRNA molecules convey biological information both in their linear sequence and in their base-paired secondary and tertiary structures. Chemical probing experiments, which involve treating an RNA with a reagent that modifies conformationally dynamic nucleotides, have… read more here.
Keywords: rna structure; chemical probing; rna; single molecule ... See more keywords
Web-based platform for analysis of RNA folding from high throughput chemical probing data
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac435
Abstract: Abstract RNA structures play critical roles in regulating gene expression across all domains of life and viruses. Chemical probing methods coupled with massively parallel sequencing have revolutionized the RNA structure field by enabling the assessment… read more here.
Keywords: web based; based platform; rna; analysis ... See more keywords