Chemical proteomic analysis of 6-benzylaminopurine molecular partners in wheat grains
Sign Up to like & getrecommendations! Published in 2017 at "Plant Cell Reports"
DOI: 10.1007/s00299-017-2174-4
Abstract: Key messageAn affinity-based chemical proteomic technique enabled direct identification of BAP-interacting proteins in wheat, including the well-known cytokinin-binder, cytokinin-binding protein 1.AbstractIn this work, we show the development of a chemical proteomic technique for the identification… read more here.
Keywords: affinity; proteomic analysis; chemical proteomic; wheat grains ... See more keywords
Chemical Proteomic Profiling of the Interacting Proteins of Isoprenoid Pyrophosphates.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01676
Abstract: Isoprenoid pyrophosphates are involved in protein prenylation and assume regulatory roles in cells; however, little is known about the cellular proteins that can interact with isoprenoid pyrophosphates. Here, we devised a chemical proteomic strategy, capitalizing… read more here.
Keywords: gpp; binding proteins; proteomic profiling; isoprenoid pyrophosphates ... See more keywords
Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00346
Abstract: Idiosyncratic liver toxicity represents an important problem in drug research and pharmacotherapy. Reactive drug metabolites that modify proteins are thought to be a principal factor in drug-induced liver injury. Here, we describe a quantitative chemical… read more here.
Keywords: targets reactive; drug metabolites; drug; reactive drug ... See more keywords
Chemical proteomic profiling reveals protein interactors of the alarmones diadenosine triphosphate and tetraphosphate
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26075-4
Abstract: The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) are formed in prokaryotic and eukaryotic cells. Since their concentrations increase significantly upon cellular stress, they are considered to be alarmones triggering stress adaptive processes. However,… read more here.
Keywords: profiling reveals; protein interactors; reveals protein; proteomic profiling ... See more keywords
Different chemical proteomic approaches to identify the targets of lapatinib
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2183809
Abstract: Abstract The process of identifying the protein targets and off-targets of a biologically active compound is of great importance in modern drug discovery. Various chemical proteomics approaches have been established for this purpose. To compare… read more here.
Keywords: different chemical; identify targets; chemical proteomic; chemistry ... See more keywords