Metabolic Chemical Reporters of Glycans Exhibit Cell‐Type‐Selective Metabolism and Glycoprotein Labeling
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DOI: 10.1002/cbic.201700020
Abstract: Since the pioneering work by Reutter and co‐workers that demonstrated structural flexibility in the carbohydrate biosynthesis and glycosylation pathways, many different labs have used unnatural monosaccharide analogues to perform glycan engineering on the surface of… read more here.
Keywords: chemical reporters; cell type; reporters glycans; metabolic chemical ... See more keywords
Azide‐ and Alkyne‐Bearing Metabolic Chemical Reporters of Glycosylation Show Structure‐Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway
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DOI: 10.1002/cbic.201800280
Abstract: Metabolic chemical reporters (MCRs) of protein glycosylation are analogues of natural monosaccharides that bear reactive groups, like azides and alkynes. When they are added to living cells and organisms, these small molecules are biosynthetically transformed… read more here.
Keywords: metabolic chemical; biosynthetic pathway; hexosamine biosynthetic; chemical reporters ... See more keywords
Chemical Reporters for Bacterial Glycans: Development and Applications.
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DOI: 10.1021/acs.chemrev.1c00729
Abstract: Bacteria possess an extraordinary repertoire of cell envelope glycans that have critical physiological functions. Pathogenic bacteria have glycans that are essential for growth and virulence but are absent from humans, making them high-priority targets for… read more here.
Keywords: applications chemical; development applications; bacterial glycans; chemical reporters ... See more keywords