Direct chemical induction of hepatocyte‐like cells with capacity for liver repopulation
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32686
Abstract: Background and Aims: Cell fate can be directly reprogrammed from accessible cell types (e.g., fibroblasts) into functional cell types by exposure to small molecule stimuli. However, no chemical reprogramming method has been reported to date… read more here.
Keywords: chemical reprogramming; hepatocyte; hepatocyte like; like cells ... See more keywords
Chemical reprogramming of melanocytes to skeletal muscle cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.13155
Abstract: Direct cell‐fate conversion by chemical reprogramming is promising for regenerative cell therapies. However, this process requires the reactivation of a set of master transcription factors (TFs) of the target cell type, which has proven challenging… read more here.
Keywords: melanocytes skeletal; chemical reprogramming; muscle cells; muscle ... See more keywords
Chemical reprogramming of human somatic cells to pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04593-5
Abstract: Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1-3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4-7.… read more here.
Keywords: chemical reprogramming; pluripotent stem; human somatic; stem cells ... See more keywords