A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.
Sign Up to like & getrecommendations! Published in 2019 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2018.10.020
Abstract: The expansion of GGGGCC repeats within the first intron of C9ORF72 constitutes the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Through repeat-associated non-ATG translation, these expansions are translated into dipeptide… read more here.
Keywords: bet bromodomain; toxicity; chemical screen; c9orf72 ... See more keywords
A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.29145
Abstract: The neural crest is a dynamic progenitor cell population that arises at the border of neural and non-neural ectoderm. The inductive roles of FGF, Wnt, and BMP at the neural plate border are well established,… read more here.
Keywords: crest development; required neural; chemical screen; crest ... See more keywords