A Chemical Signature for Cytidine Acetylation in RNA.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b06636
Abstract: N4-acetylcytidine (ac4C) is a highly conserved modified RNA nucleobase whose formation is catalyzed by the disease-associated N-acetyltransferase 10 (NAT10). Here we report a sensitive chemical method to localize ac4C in RNA. Specifically, we characterize the… read more here.
Keywords: acetylation; cytidine acetylation; signature cytidine; acetylation rna ... See more keywords
A bifunctional chemical signature enabling RNA 4-thiouridine enrichment sequencing with single-base resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06080e
Abstract: Both sequence enrichment and base resolution are essential for accurate sequencing analysis of low-abundance RNA. Yet they are hindered by the lack of molecular tools. Here we report a bifunctional chemical signature for RNA 4-thiouridine… read more here.
Keywords: base resolution; chemical signature; single base; enrichment ... See more keywords