A Chemical switch for transforming a purine agonist for Toll-like receptor 7 to a clinically relevant antagonist.
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DOI: 10.1021/acs.jmedchem.0c00011
Abstract: Toll-like receptor 7 (TLR7) is an established therapeutic target in myriad autoimmune disorders, but no TLR7 antagonist is available for clinical use to date. Herein we report a purine scaffold TLR7 antagonist, first-of-its-kind to our… read more here.
Keywords: toll like; chemical switch; like receptor; clinically relevant ... See more keywords