Natural products as chemical tools to dissect complex biology in C. elegans.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2019.03.005
Abstract: The search for novel pheromones, hormones, and other types of natural products in the nematode Caenorhabditis elegans has accelerated over the last 10-15 years. Many of these natural products perturb fundamental processes such as developmental… read more here.
Keywords: chemical tools; natural products; dissect complex; tools dissect ... See more keywords
Chemical tools to characterize peptidoglycan synthases.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2019.07.009
Abstract: The peptidoglycan cell wall is a unique macromolecular structure in bacteria that defines their shape and confers protection from the surrounding environment. Decades of research has focused on understanding the peptidoglycan synthesis pathway and exploiting… read more here.
Keywords: peptidoglycan synthases; tools characterize; chemical tools; characterize peptidoglycan ... See more keywords
Probing Biological Mechanisms with Chemical Tools.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.104656
Abstract: Traditionally small molecules have mainly been used to inhibit biochemical activities of proteins, however such compounds can also be used to change the conformational energy landscape of proteins. Tool compounds that allosterically modulate protein conformations… read more here.
Keywords: chemical tools; probing biological; biological mechanisms; mechanisms chemical ... See more keywords
Chemical Tools for the Study of DNA Repair.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00608
Abstract: ConspectusDNA repair enzymes continuously provide surveillance throughout our cells, protecting the enclosed DNA from the damage that is constantly arising from oxidation, alkylating species, and radiation. Members of this enzyme class are intimately linked to… read more here.
Keywords: dna repair; base excision; study dna; chemical tools ... See more keywords
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24821-2
Abstract: Diseases are a manifestation of how thousands of proteins interact. In several diseases, such as cancer and Alzheimer’s disease, proteome-wide disturbances in protein-protein interactions are caused by alterations to chaperome scaffolds termed epichaperomes. Epichaperome-directed chemical… read more here.
Keywords: chemical tools; nervous system; central nervous; epichaperome mediated ... See more keywords
Chemical tools for study and modulation of biomolecular phase transitions
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04907d
Abstract: Biomolecular phase transitions play an important role in organizing cellular processes in space and time. Methods and tools for studying these transitions, and the intrinsically disordered proteins (IDPs) that often drive them, are typically less… read more here.
Keywords: chemical tools; phase transitions; phase; biomolecular phase ... See more keywords
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
Sign Up to like & getrecommendations! Published in 2018 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2017.0083
Abstract: Sirtuins are NAD+-dependent protein deacylases capable of cleaving off acetyl as well as other acyl groups from the ɛ-amino group of lysines in histones and other substrate proteins. They have been reported as promising drug… read more here.
Keywords: nad dependent; new chemical; chemical tools; lysine ... See more keywords
Covalent Chemical Tools for Profiling Post-Translational Modifications
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.868773
Abstract: Nature increases the functional diversity of the proteome through posttranslational modifications (PTMs); a process that involves the proteolytic processing or catalytic attachment of diverse functional groups onto proteins. These modifications modulate a host of biological… read more here.
Keywords: post translational; tools profiling; chemical tools; covalent chemical ... See more keywords
The Development and Application of Opto-Chemical Tools in the Zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196231
Abstract: The zebrafish is one of the most widely adopted animal models in both basic and translational research. This popularity of the zebrafish results from several advantages such as a high degree of similarity to the… read more here.
Keywords: opto chemical; development application; application opto; chemical tools ... See more keywords