Stem Cell-Based Methods to Predict Developmental Chemical Toxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7899-1_21
Abstract: Human pluripotent stem cells such as embryonic stem (ES) and induced pluripotent stem (iPS) cells, combined with sophisticated bioinformatics methods, are powerful tools to predict developmental chemical toxicity. Because cell differentiation is not necessary, these… read more here.
Keywords: developmental chemical; toxicity; predict developmental; stem ... See more keywords
Modern Approaches to Chemical Toxicity Screening.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in electrochemistry"
DOI: 10.1016/j.coelec.2017.03.013
Abstract: Chemical toxicity has a serious impact on public health, and toxicity failures of drug candidates drive up drug development costs. Many in vitro bioassays exist for toxicity screening, and newer versions of these tend to… read more here.
Keywords: modern approaches; toxicity screening; toxicity; approaches chemical ... See more keywords
Advancing Computational Toxicology by Interpretable Machine Learning.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental science & technology"
DOI: 10.1021/acs.est.3c00653
Abstract: Chemical toxicity evaluations for drugs, consumer products, and environmental chemicals have a critical impact on human health. Traditional animal models to evaluate chemical toxicity are expensive, time-consuming, and often fail to detect toxicants in humans.… read more here.
Keywords: toxicology; machine learning; toxicity; chemical toxicity ... See more keywords
Prediction of developmental chemical toxicity based on gene networks of human embryonic stem cells
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1285
Abstract: 1Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan, 2Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo… read more here.
Keywords: medicine; developmental chemical; japan; biology ... See more keywords
Chemical toxicity prediction based on semi-supervised learning and graph convolutional neural network
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cheminformatics"
DOI: 10.1186/s13321-021-00570-8
Abstract: As safety is one of the most important properties of drugs, chemical toxicology prediction has received increasing attentions in the drug discovery research. Traditionally, researchers rely on in vitro and in vivo experiments to test… read more here.
Keywords: toxicity; ssl; prediction; supervised learning ... See more keywords
SApredictor: An Expert System for Screening Chemicals Against Structural Alerts
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.916614
Abstract: The rapid and accurate evaluation of chemical toxicity is of great significance for estimation of chemical safety. In the past decades, a great number of excellent computational models have been developed for chemical toxicity prediction.… read more here.
Keywords: chemicals structural; toxicity; screening chemicals; sapredictor ... See more keywords
HiPSC-Derived Hepatocyte-like Cells Can Be Used as a Model for Transcriptomics-Based Study of Chemical Toxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Toxics"
DOI: 10.3390/toxics10010001
Abstract: Traditional toxicity risk assessment approaches have until recently focussed mainly on histochemical readouts for cell death. Modern toxicology methods attempt to deduce a mechanistic understanding of pathways involved in the development of toxicity, by using… read more here.
Keywords: hipsc derived; like cells; toxicity; hlcs ... See more keywords
Predicting Dose-Range Chemical Toxicity using Novel Hybrid Deep Machine-Learning Method
Sign Up to like & getrecommendations! Published in 2022 at "Toxics"
DOI: 10.3390/toxics10110706
Abstract: Humans are exposed to thousands of chemicals, including environmental chemicals. Unfortunately, little is known about their potential toxicity, as determining the toxicity remains challenging due to the substantial resources required to assess a chemical in… read more here.
Keywords: hnn tox; dose range; toxicity; chemical toxicity ... See more keywords