Quantification of Chemical Uptake into the Skin by Vibrational Spectroscopies and Stratum Corneum Sampling
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c01109
Abstract: Evaluation of the bioavailability of drugs intended to act within the skin following the application of complex topical products requires the application of multiple experimental tools, which must be quantitative, validated, and, ideally and ultimately,… read more here.
Keywords: chemical uptake; quantification chemical; stratum corneum; chemical ... See more keywords
Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures
Sign Up to like & getrecommendations! Published in 2018 at "BMC Systems Biology"
DOI: 10.1186/s12918-018-0601-y
Abstract: BackgroundA challenge of in vitro to in vivo extrapolation (IVIVE) is to predict the physical state of organisms exposed to chemicals in the environment from in vitro exposure assay data. Although toxicokinetic modeling approaches promise… read more here.
Keywords: bioconcentration; chemical uptake; diverse chemical; chemical ... See more keywords