Chemiexcitation and Its Implications for Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.04.004
Abstract: Quantum mechanics rarely extends to molecular medicine. Recently, the pigment melanin was found to be susceptible to chemiexcitation, in which an electron is chemically excited to a high-energy molecular orbital. In invertebrates, chemiexcitation causes bioluminescence;… read more here.
Keywords: medicine; implications disease; chemiexcitation; melanin ... See more keywords
Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216935120
Abstract: Significance Regarding basic science, we report a physical chemistry mechanism involved in turnover of spent photoreceptor discs, a process essential for reusing retinal and preventing lipofuscin that leads to age-related macular degeneration. We show that… read more here.
Keywords: macular degeneration; chemistry; melanin; chemiexcitation ... See more keywords
Theoretical Analysis of the Effect Provoked by Bromine-Addition on the Thermolysis and Chemiexcitation of a Model Dioxetanone
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Chemistry"
DOI: 10.1155/2017/1903981
Abstract: Chemi-/bioluminescence are phenomena in which chemical energy is converted into electronically excited singlet states, which decay with light emission. Given this feature, along with high quantum yields and other beneficial characteristics, these systems have gained… read more here.
Keywords: chemiexcitation model; chemiexcitation; effect; thermolysis ... See more keywords
Tuning the Intramolecular Chemiexcitation of Neutral Dioxetanones by Interaction with Ionic Species
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123861
Abstract: The intramolecular chemiexcitation of high-energy peroxide intermediates, such as dioxetanones, is an essential step in different chemi- and bioluminescent reactions. Here, we employed the Time-Dependent Density Functional Theory (TD-DFT) methodology to evaluate if and how… read more here.
Keywords: ionic species; neutral dioxetanones; tuning intramolecular; intramolecular chemiexcitation ... See more keywords