AI and computational chemistry-accelerated development of an alotaketal analogue with conventional PKC selectivity.
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DOI: 10.1039/d2cc01759h
Abstract: The protein kinase C (PKC) family consists of ten isozymes and is a potential target for treating cancer, Alzheimer's disease, and HIV infection. Since known natural PKC agonists have little selectivity among the PKC isozymes,… read more here.
Keywords: computational chemistry; chemistry; pkc ligands; chemistry accelerated ... See more keywords