Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c00281
Abstract: Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the design of potent… read more here.
Keywords: adp ribosylating; medicinal chemistry; chemistry; chemistry perspective ... See more keywords
Fluorine in Medicinal Chemistry: In Perspective to COVID-19
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DOI: 10.1021/acsomega.2c01121
Abstract: Over two years into the outbreak of COVID-19, the quest for effective and economical drugs has become starkly clear to reduce the risk of progression of coronavirus disease. A number of drugs have been investigated,… read more here.
Keywords: anti covid; medicinal chemistry; chemistry; chemistry perspective ... See more keywords
Designer drugs: a medicinal chemistry perspective (II)
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the New York Academy of Sciences"
DOI: 10.1111/nyas.14349
Abstract: During 2012–2018, the clandestine manufacture of new psychoactive substances (NPS) designed to circumvent substance control regulations increased exponentially worldwide, with concomitant increase in fatalities. This review focuses on three compound classes identified as synthetic opioids,… read more here.
Keywords: medicinal chemistry; chemistry; drugs medicinal; designer drugs ... See more keywords