A Practical Synthesis of Valuable Strained Eight‐Membered‐Ring Derivatives for Click Chemistry
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DOI: 10.1002/ejoc.201800139
Abstract: A convenient and cost-effective synthetic access to cyclooctyne and trans-cyclooctene derivatives is described. A cyclopropanation step using copper powder in lieu of Rh₂(OAc)₄ as catalyst and a symmetric diazomalonate enabled to drastically reduce the overall… read more here.
Keywords: click chemistry; practical synthesis; chemistry; chemistry practical ... See more keywords