Chemistry, structure, and biological roles of Au-NHC complexes as TrxR inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103552
Abstract: In recent years, the preparation of metal complexes and the introduction of biologically active organometalic compounds are new strategies in drug development. For this purpose, generally N-heterocyclic pharmaceutical agents have been used as promising nuclei.… read more here.
Keywords: complexes trxr; chemistry structure; trxr inhibition; chemistry ... See more keywords
Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review
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DOI: 10.1039/d2ra01781d
Abstract: The interest in acyl thioureas has continually been escalating owing to their extensive applications in diverse fields, such as synthetic precursors of new heterocycles, pharmacological and materials science, and technology. These scaffolds exhibit a wide… read more here.
Keywords: recent trends; chemistry structure; trends chemistry; chemistry ... See more keywords
Chemistry, structure and function of approved oligonucleotide therapeutics
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad067
Abstract: Abstract Eighteen nucleic acid therapeutics have been approved for treatment of various diseases in the last 25 years. Their modes of action include antisense oligonucleotides (ASOs), splice-switching oligonucleotides (SSOs), RNA interference (RNAi) and an RNA… read more here.
Keywords: function approved; chemistry structure; structure function; chemistry ... See more keywords