pH/Cathepsin B Hierarchical‐Responsive Nanoconjugates for Enhanced Tumor Penetration and Chemo‐Immunotherapy
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202003757
Abstract: An ideal cancer nanomedicine should precisely deliver therapeutics to its intracellular target within tumor cells. However, the multiple biological barriers seriously hinder their delivery efficiency, leading to unsatisfactory therapeutic outcome. Herein, pH/cathepsin B hierarchical‐responsive nanoconjugates… read more here.
Keywords: tumor; chemo immunotherapy; cathepsin hierarchical; responsive nanoconjugates ... See more keywords
Retrospective analysis on R‐DHAP/OX and ASCT as salvage treatment for relapsed/refractory high‐risk follicular lymphoma
Sign Up to like & getrecommendations! Published in 2017 at "Hematological Oncology"
DOI: 10.1002/hon.2439_119
Abstract: The outcome of patients with follicular lymphoma (FL) experiencing disease progression within the first two years from first-line chemo-immunotherapy is poor and optimal subsequent management is uncertain. The combination of rituximab, dexamethasone, high-dose cytarabine, and… read more here.
Keywords: dhap; line; first line; chemo immunotherapy ... See more keywords
Reinforcing the Induction of Immunogenic Cell Death Via Artificial Engineered Cascade Bioreactor-Enhanced Chemo-Immunotherapy for Optimizing Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202101897
Abstract: Traditional chemo-immunotherapy can elicit T cell immune response by inducing immunogenic cell death (ICD), however, insufficient ICD limits the lasting antitumor immunotherapeutic efficacy. Herein, tadpole-ovoid manganese-doped hollow mesoporous silica coated gold nanoparticles (Au@HMnMSNs) as biodegradable… read more here.
Keywords: immunogenic cell; immunotherapy; chemo immunotherapy; cascade ... See more keywords
A Three‐in‐One Nanoscale Coordination Polymer for Potent Chemo‐Immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Small Methods"
DOI: 10.1002/smtd.202201437
Abstract: The addition of immune checkpoint blockade to standard chemotherapy has changed the standards of care for some cancer patients. However, current chemo‐immunotherapy strategies do not benefit most colorectal cancer patients and many triple‐negative breast cancer… read more here.
Keywords: three one; one nanoscale; chemo immunotherapy; cancer ... See more keywords
Robust Optimal Control-based Design of Combined Chemo- and Immunotherapy Delivery Profiles
Sign Up to like & getrecommendations! Published in 2019 at "IFAC-PapersOnLine"
DOI: 10.1016/j.ifacol.2019.12.239
Abstract: Abstract This paper addresses the problem of drug injection schedules design for cancer treatment, in the presence of model parametric uncertainties. It is commonly known that achieving optimal recovery performances under uncertainties is a complex… read more here.
Keywords: chemo immunotherapy; control; robust optimal; control based ... See more keywords
Front-line chemo-immunotherapy with carboplatin-paclitaxel using oregovomab indirect immunization in advanced ovarian cancer: A randomized phase II study.
Sign Up to like & getrecommendations! Published in 2020 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2019.12.024
Abstract: BACKGROUND This randomized phase II study tested the hypothesis that schedule dependent chemo-immunotherapy with oregovomab improves progression free survival (PFS) and overall survival (OS) in optimally resected, Stage III/IV ovarian cancer. METHODS Patients from both… read more here.
Keywords: chemo immunotherapy; study; randomized phase; ovarian cancer ... See more keywords
Co-Delivery of Doxorubicin and Anti-PD-L1 Peptide in Lipid/PLGA Nanocomplexes for the Chemo-Immunotherapy of Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00611
Abstract: The combined delivery of chemotherapeutics with checkpoint inhibitors of the PD-1/PD-L1 pathway provides a new approach for cancer treatment. Small-molecule peptide inhibitors possess short production cycle, low immunogenicity, and fewer side effects; however, their potential… read more here.
Keywords: immunotherapy cancer; doxorubicin; plga; chemo immunotherapy ... See more keywords
Self-Assembled Immunostimulatory Tetrahedral Framework Nucleic Acid Vehicles for Tumor Chemo-immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c09462
Abstract: Some chemotherapeutic agents, such as anthracyclines and oxaliplatin, can induce immunogenic cell death (ICD) with additional immune responses against cancer. However, ICD-based immunotherapy is limited by the nonspecific distribution of drugs and various side effects.… read more here.
Keywords: immunotherapy; self assembled; tetrahedral framework; chemo immunotherapy ... See more keywords
Hierarchical Microparticles Delivering Oxaliplatin and NLG919 Nanoprodrugs for Local Chemo-immunotherapy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c16564
Abstract: Chemo-immunotherapy shows promising antitumor therapeutic outcomes for many primary cancers. Research in this area has been focusing on developing an ideal formula that enables the potent efficacy of chemo-immunotherapy in combating various cancers with reduced… read more here.
Keywords: delivering oxaliplatin; oxaliplatin nlg919; nlg919 nanoprodrugs; chemo immunotherapy ... See more keywords
Immunostimulant In Situ Fibrin Gel for Post-operative Glioblastoma Treatment by Macrophage Reprogramming and Photo-Chemo-Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.3c00468
Abstract: Tumor recurrence remains the leading cause of treatment failure following surgical resection of glioblastoma (GBM). M2-like tumor-associated macrophages (TAMs) infiltrating the tumor tissue promote tumor progression and seriously impair the efficacy of chemotherapy and immunotherapy.… read more here.
Keywords: photo chemo; gel; chemo immunotherapy; treatment ... See more keywords
Nanoparticle-Mediated CD47-SIRPα Blockade and Calreticulin Exposure for Improved Cancer Chemo-Immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.2c08240
Abstract: Enabling macrophages to phagocytose tumor cells holds great potential for cancer therapy but suffers from tremendous challenges because the tumor cells upregulate antiphagocytosis molecules (such as CD47) on their surface. The blockade of CD47 alone… read more here.
Keywords: chemo immunotherapy; cancer chemo; tumor; cancer ... See more keywords