Multifunctional MOF-based Microneedle Patch with Synergistic Chemo-photodynamic Antibacterial Effect and Sustained Release of Growth Factor for Chronic Wound Healing.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300250
Abstract: Chronic wound healing is a major challenge in biomedicine. Conventional therapies are usually associated with poor drug permeability, low bioavailability, risk of antimicrobial resistance, and require frequent administration. Therefore, a novel formulation with a reduced… read more here.
Keywords: photodynamic antibacterial; release growth; wound healing; chronic wound ... See more keywords
Programmed Size-Changeable Nanotheranostic Agents for Enhanced Imaging-Guided Chemo/Photodynamic Combination Therapy and Fast Elimination.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202100398
Abstract: An ideal nanotheranostic agent should be able to achieve efficient tumor accumulation, retention, and fast elimination after its theranostic functions exhausts. However, there is an irreconcilable contradiction on optimum sizes for effective tumor retention and… read more here.
Keywords: tumor; fast elimination; photodynamic combination; chemo photodynamic ... See more keywords
The potentiated checkpoint blockade immunotherapy by ROS-responsive nanocarrier-mediated cascade chemo-photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119469
Abstract: Checkpoint inhibitors, such as anti-PD-1/PD-L1 antibodies, have been proven as a promising type of immunotherapy in a number of cancers, but the relatively low response rates limit their scope of clinical application. Here, we report… read more here.
Keywords: photodynamic therapy; chemo; chemo photodynamic; cascade chemo ... See more keywords
Long circulating photoactivable nanomicelles with tumor localized activation and ROS triggered self-accelerating drug release for enhanced locoregional chemo-photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119702
Abstract: Although chemo-photodynamic therapy demonstrates promising synergetic therapeutic effect in malignant cancers, the currently available nanocarriers offer the limited capabilities for selective toxicity, drug release and tumor penetration. Herein, we developed photoactivatable nanomicelles, which are constructed… read more here.
Keywords: locoregional chemo; photodynamic therapy; chemo photodynamic; release ... See more keywords
Chitosan/hyaluronan nanogels co-delivering methotrexate and 5-aminolevulinic acid: A combined chemo-photodynamic therapy for psoriasis.
Sign Up to like & getrecommendations! Published in 2022 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118819
Abstract: Psoriasis does not respond adequately to the monotherapy, tailoring combined strategies for synergistical treatment remains challenging. We fabricated chitosan/hyaluronan nanogels to co-load methotrexate (MTX) and 5-aminoleavulinic acid (ALA), i.e., MTX-ALA NGs, for a combined chemo-photodynamic… read more here.
Keywords: mtx ala; combined chemo; chitosan hyaluronan; chemo photodynamic ... See more keywords
Layer structured LDH_ZnPcG4-FA nanoplatform for targeted and imaging guided chemo-photodynamic therapy mediated by 650 nm light
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2019.122847
Abstract: Abstract Designing a phototherapeutic material that simultaneously has target, tumor microenvironment (TME)-response, high-quality imaging and synergistic therapy has attracted much attention in anticancer field. Herein, a novel stimuli-responsive multifunctional nanoplatform has been constructed by inserting… read more here.
Keywords: znpcg4; nanoplatform; chemo photodynamic; dox ... See more keywords
A Unique Chemo-photodynamic Antitumor Approach to Suppress Hypoxia via Ultrathin Graphitic Carbon Nitride Nanosheets Supported a Platinum(IV) Prodrug.
Sign Up to like & getrecommendations! Published in 2022 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.2c02806
Abstract: Tumor hypoxia severely restrains the efficiency of irreversible O2-consumption photodynamic therapy. The deep hypoxia induced by photodynamic therapy can promote the level of hypoxia inducible factor 1α that participates in many tumor processes and eventually… read more here.
Keywords: graphitic carbon; photodynamic antitumor; ultrathin graphitic; hypoxia ... See more keywords
Glycosylated BODIPY- Incorporated Pt(II) Metallacycles for Targeted and Synergistic Chemo-Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01940
Abstract: Pt(II)-BODIPY complexes combine the chemotherapeutic activity of Pt(II) with the photocytotoxicity of BODIPYs. Additional conjugation with targeting ligands can boost the uptake by cancer cells that overexpress the corresponding receptors. We describe two Pt(II) triangles,… read more here.
Keywords: metallacycles targeted; incorporated metallacycles; glycosylated bodipy; chemo photodynamic ... See more keywords
Hybrid lipid polymer nanoparticles for combined chemo- and photodynamic therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00797
Abstract: Retinoblastoma is a malignant tumor of the retina in infants. Conventional therapies are associated to severe side effects and some of them induce secondary tumors. Photodynamic therapy (PDT) thus appears as a promising alternative as… read more here.
Keywords: hybrid lipid; photodynamic therapy; microscopy; combined chemo ... See more keywords
Cucurbit[7]uril-Based Supramolecular DNA Nanogel for Targeted Codelivery of Chemo/Photodynamic Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00763
Abstract: Nanodrug delivery systems for the delivery of combination therapeutics have shown their exceptionally potential clinical application by facilitating better synergistic anticancer effects. Herein, we developed a universal strategy to fabricate supramolecular DNA nanogels from DNA… read more here.
Keywords: cucurbit uril; dna; uril based; chemo photodynamic ... See more keywords
A multifunctional nanoplatform based on mesoporous silica nanoparticles for imaging-guided chemo/photodynamic synergetic therapy
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c7ra04549b
Abstract: Multifunctional nanoplatforms based on mesoporous silica nanoparticles (MSNs) have recently shown great promise in drug delivery and therapy. Herein, a multifunctional nanoplatform based on MSNs is fabricated by a modified micro-emulsion method for drug delivery… read more here.
Keywords: mesoporous silica; chemo photodynamic; based mesoporous; therapy ... See more keywords