Copper-Catalyzed Chemo-, Regio-, and Stereoselective Multicomponent 1,2,3-Trifunctionalization of Internal Alkynes.
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DOI: 10.1021/acs.orglett.2c00499
Abstract: Herein, we report the first diaryliodonium salts promoted multicomponent 1,2,3-trifunctionalization of alkynes, where both the acetylenic bond and the adjacent nonactivated propargylic C(sp3)-H bond were functionalized synergistically to generate α-arylated enones with high chemo-, regio-,… read more here.
Keywords: multicomponent trifunctionalization; chemo regio; internal alkynes;
Highly Chemo-, Regio- and E/Z-Selective Intermolecular Heck-Type Dearomative [2 + 2 + 1] Spiroannulation of Alkyl Bromoarenes with Internal Alkynes.
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DOI: 10.1021/acs.orglett.9b00099
Abstract: Described herein is a palladium-catalyzed dearomative annulation of alkyl bromoarenes with internal alkynes. Challenges in this spiroannulation include the chemoselectivity among [2 + 2 + 1], [2 + 2 + 2], and [3 + 2]… read more here.
Keywords: heck type; internal alkynes; alkyl bromoarenes; bromoarenes internal ... See more keywords
Chemo-, regio-, and enantioselective synthesis of allylic nitrones via rhodium-catalyzed addition of oximes to allenes.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03391b
Abstract: The first chemo-, regio-, and enantioselective rhodium-catalyzed addition of oximes to allenes is reported. Using a Rh(i)/Josiphos catalyst system under mild conditions, the construction of allylic C-N bonds instead of C-O bonds was achieved. This… read more here.
Keywords: catalyzed addition; regio enantioselective; rhodium catalyzed; oximes allenes ... See more keywords
Chemo- and regio-divergent access to fluorinated 1-alkyl and 1-acyl triazenes from alkynyl triazenes
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DOI: 10.1039/d2sc00294a
Abstract: The 1,1,2,2-tetrafluoroethylene unit is prevalent in bioactive molecules and functional materials. Despite being in principle a straightforward strategy to access this motif, the direct tetrafluorination of alkynes involves very hazardous or inconvenient reagents. Therefore, safer… read more here.
Keywords: fluorinated alkyl; chemo regio; regio divergent; alkynyl triazenes ... See more keywords