Nickel-Catalyzed Chemo- and Regioselective Arylcyanation of β,γ-Unsaturated Amides.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01360
Abstract: A nickel-catalyzed intermolecular arylcyanation of 8-aminoquinolinyl β,γ-unsaturated amides is reported. The three-component reaction directly afforded diverse β-cyano γ-aryl amides with exclusive chemo- and regioselectivity. The synthetic practicality of this approach is further demonstrated through multigram… read more here.
Keywords: catalyzed chemo; nickel catalyzed; regioselective arylcyanation; unsaturated amides ... See more keywords
Total Synthesis of (+)-Pochonin D and (+)-Monocillin II via Chemo- and Regioselective Intramolecular Nitrile Oxide Cycloaddition.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03054
Abstract: Asymmetric total syntheses of (+)-pochonin D (1) and (+)-monocillin II (2), Hsp90 inhibitors with potent anticancer activity, have been accomplished where the macrolactone 3 was constructed through a chemo- and regioselective intramolecular nitrile oxide cycloaddition… read more here.
Keywords: regioselective intramolecular; nitrile oxide; pochonin monocillin; chemo regioselective ... See more keywords
Chemo- and Regioselective Organo-Photoredox Catalyzed Hydroformylation of Styrenes via a Radical Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05082
Abstract: An unprecedented, chemo- and regioselective, organo-photoredox catalyzed hydroformylation reaction of aryl olefins with diethoxyacetic acid as the formylation reagent is described. In contrast to traditional transition metal promoted ionic hydroformylation reactions, the new process follows… read more here.
Keywords: hydroformylation; photoredox catalyzed; chemo regioselective; photoredox ... See more keywords
Chemo- and Regioselective Lysine Modification on Native Proteins
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DOI: 10.1021/jacs.7b12874
Abstract: Site-selective chemical conjugation of synthetic molecules to proteins expands their functional and therapeutic capacity. Current protein modification methods, based on synthetic and biochemical technologies, can achieve site selectivity, but these techniques often require extensive sequence… read more here.
Keywords: lysine; chemo regioselective; site; regioselective lysine ... See more keywords
Transition-metal-free chemo- and regioselective vinylation of azaallyls
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DOI: 10.1038/nchem.2760
Abstract: Direct C(sp3)–C(sp2) bond formation under transition-metal-free conditions offers an atom-economical, inexpensive and environmentally benign alternative to traditional transition-metal-catalysed cross-coupling reactions. A new chemo- and regioselective coupling protocol between 3-aryl-substituted-1,1-diphenyl-2-azaallyl derivatives and vinyl bromides has been… read more here.
Keywords: transition metal; transition; chemo regioselective; metal free ... See more keywords
Substrate-directed chemo- and regioselective synthesis of polyfunctionalized trifluoromethylarenes via organocatalytic benzannulation
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01436e
Abstract: Highly chemo- and regioselective substrate-directed benzannulation of trisubstituted CF3-alkenes and 2-benzylidenemalononitriles or 2-nitroallylic acetates has been achieved via Michael-initiated [4 + 2] or Rauhut–Currier-initiated [3 + 3] annulation. These protocols enable the rapid assembly of… read more here.
Keywords: synthesis polyfunctionalized; chemo regioselective; substrate directed; directed chemo ... See more keywords
Chemo- and Regioselective Palladium(II)-Catalyzed Aminoarylation of N-Allylureas Providing 4-Arylmethyl Imidazolidinones
Sign Up to like & getrecommendations! Published in 2019 at "Synthesis"
DOI: 10.1055/s-0037-1611539
Abstract: The aminoarylation reaction of N-allylureas under oxidative palladium catalysis, in the absence of ligands and by using inexpensive H2O2 as the sole oxidant, occurs in a chemo- and regioselective fashion. This intramolecular process takes place… read more here.
Keywords: regioselective palladium; chemo regioselective; arylmethyl imidazolidinones; palladium catalyzed ... See more keywords